ArticleImmunity2018
Expression of the DNA-Binding Factor TOX Promotes the Encephalitogenic Potential of Microbe-Induced Autoreactive CD8
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in Immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 45 papers.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 86 citations in OpenAlex.
- TOX drives CD4Nature immunology · 2026Article
- Combined targeted and epigenetic-based therapy enhances antitumor immunity by stabilizing GATA6-dependent MHCI expression in pancreatic ductal adenocarcinoma.Nature communications · 2026Article
- From exhaustion to functional cure: frontiers in reversing HBV-specific T-cell immunity.Frontiers in immunology · 2026Review
- In vivo imaging of the barrier properties of the glia limitans during health and neuroinflammation.Nature communications · 2025Article
- Neuron-reactive KIRNature communications · 2025Article
- LARP4-mediated hypertranslation drives T cell dysfunction in tumors.Nature immunology · 2025Article
- Lack of junctional adhesion molecule (JAM)-B traps CD8 T cells in CNS border zones and ameliorates autoimmune neuroinflammation.Acta neuropathologica communications · 2025Article
- TOX, through a glass, darkly.Frontiers in immunology · 2025Review
- SLAMF7 defines subsets of human effector CD8 T cells.Scientific reports · 2024Article
- Single-cell characterisation of tissue homing CD4 + and CD8 + T cell clones in immune-mediated refractory arthritis.Molecular medicine (Cambridge, Mass.) · 2024Article
- Complementary HLH susceptibility factors converge on CD8 T-cell hyperactivation.Blood advances · 2023Article
- Immunotherapy targeting different immune compartments in combination with radiation therapy induces regression of resistant tumors.Nature communications · 2023Article
- The Tox Gene Encodes Two Proteins with Distinct and Shared Roles in Gene Regulation.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Antigen recognition detains CD8Nature communications · 2023Article
- BET inhibitors rescue anti-PD1 resistance by enhancing TCF7 accessibility in leukemia-derived terminally exhausted CD8Leukemia · 2023Article
- Tox induces T cell IL-10 production in a BATF-dependent manner.Frontiers in immunology · 2023Article
- TOX deficiency facilitates the differentiation of IL-17A-producing γδ T cells to drive autoimmune hepatitis.Cellular & molecular immunology · 2022Article
- Central nervous system zoning: How brain barriers establish subdivisions for CNS immune privilege and immune surveillance.Journal of internal medicine · 2022Article
- The TOX subfamily: all-round players in the immune system.Clinical and experimental immunology · 2022Review
- Reprogramming dysfunctional CD8+ T cells to promote properties associated with natural HIV control.The Journal of clinical investigation · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
19 authors at 7 institutions in 3 countries.
Nicolas PageDepartment of Pathology and Immunology, University of Geneva, Geneva, Switzerland.
Bogna KlimekDepartment of Pathology and Immunology, University of Geneva, Geneva, Switzerland.
Mathias De RooDepartment of Anesthesiology, Pharmacology and Intensive Care, Geneva University Hospital, Switzerland; Department of Basic Neuroscience, University of Geneva Medical School, Geneva, Switzerland.
Karin SteinbachDepartment of Pathology and Immunology, University of Geneva, Geneva, Switzerland.
Hadrien SoldatiDepartment of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.
Sylvain LemeilleDepartment of Pathology and Immunology, University of Geneva, Geneva, Switzerland.
Ingrid WagnerDepartment of Pathology and Immunology, University of Geneva, Geneva, Switzerland.
Mario KreutzfeldtDepartment of Pathology and Immunology, University of Geneva, Geneva, Switzerland.
Giovanni Di LibertoDepartment of Pathology and Immunology, University of Geneva, Geneva, Switzerland.
Ilena VincentiDepartment of Pathology and Immunology, University of Geneva, Geneva, Switzerland.
Thomas LingnerMicroarray and Deep-Sequencing Core Facility, University Medical Center Göttingen, Göttingen, Germany.
Gabriela SalinasMicroarray and Deep-Sequencing Core Facility, University Medical Center Göttingen, Göttingen, Germany.
Wolfgang BrückInstitute of Neuropathology, Georg-August University Göttingen, 37075 Göttingen, Germany.
Mikael SimonsInstitute of Neuronal Cell Biology, Technical University Munich, Munich, Germany; German Center for Neurodegenerative Disease, 6250 Munich, Germany; Munich Cluster for Systems Neurology, 81377 Munich, Germany.
Rabih MurrDepartment of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland; Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, Switzerland.
Jonathan KayeResearch Division of Immunology, Departments of Biomedical Sciences and Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Dietmar ZehnDivision of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.
Daniel D PinschewerDivision of Experimental Virology, Department of Biomedicine, Haus Petersplatz, University of Basel, Basel, Switzerland.
Doron MerklerDepartment of Pathology and Immunology, University of Geneva, Geneva, Switzerland; Division of Clinical Pathology, Geneva University Hospital, Geneva, Switzerland. Electronic address: doron.merkler@unige.ch.
University of Geneva · CHUniversitätsmedizin Göttingen · DECedars-Sinai Medical Center · USGerman Center for Neurodegenerative Diseases · DETechnical University of Munich · DEUniversity of Basel · CHUniversity of Göttingen · DE
Funding
TOX, A Novel Regulator of Thymocyte SelectionR01AI054977 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI KAYE, JONATHAN G · 2004 to 2021
$6.3MNIAID NIH HHS R01 AI054977
Abstract
Infections are thought to trigger CD8
Indexed as
AdultAgedAnimalsAutoimmunityCD8-Positive T-LymphocytesFemaleHomeodomain ProteinsHumansLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMaleMice, Inbred C57BLMice, KnockoutMiddle AgedSignaling Lymphocytic Activation Molecule FamilyT-Lymphocytes, CytotoxicCd244a protein, mouseHomeodomain ProteinsRhox8 protein, mouseSignaling Lymphocytic Activation Molecule Familyautoimmunitycytotoxic T cellsexperimental autoimmune encephalomyelitisListeria monocytogeneslymphocytic choriomeningitis virusmultiple sclerosisT cell differentiationthymocyte selection-associated high-mobility group box factortranscription factor
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.