Evidence map›Paper›PMID 29768176›Full record

ArticleImmunity2018

The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport.

Karin Pelka, Damien Bertheloot, Elisa Reimer, Kshiti Phulphagar, Susanne V Schmidt, Anette Christ, Rainer Stahl, Nicki Watson, Kensuke Miyake, Nir Hacohen and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 131 citations in OpenAlex.

  1. Review
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  12. Oncolytic virus-induced IL-1βJournal for immunotherapy of cancer · 2025
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29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 3 countries.

Karin PelkaInstitute of Innate Immunity, University Hospital Bonn, 53127 Bonn, Germany; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Damien BerthelootInstitute of Innate Immunity, University Hospital Bonn, 53127 Bonn, Germany; IFM Therapeutics GmbH, 53127 Bonn, Germany.
Elisa ReimerViral Immune Modulation Research Group, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.
Kshiti PhulphagarInstitute of Innate Immunity, University Hospital Bonn, 53127 Bonn, Germany; Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
Susanne V SchmidtInstitute of Innate Immunity, University Hospital Bonn, 53127 Bonn, Germany.
Anette ChristInstitute of Innate Immunity, University Hospital Bonn, 53127 Bonn, Germany; Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Rainer StahlInstitute of Innate Immunity, University Hospital Bonn, 53127 Bonn, Germany.
Nicki WatsonW.M. Keck Microscopy Facility, the Whitehead Institute, Cambridge, MA 02142, USA.
Kensuke MiyakeDivision of Innate Immunity, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan; Laboratory of Innate Immunity, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan.
Nir HacohenBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114, USA.
Albert HaasCell Biology Institute, University of Bonn, 53121 Bonn, Germany.
Melanie M BrinkmannViral Immune Modulation Research Group, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.
Ann Marshak-RothsteinDepartment of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Felix MeissnerMax Planck Institute of Biochemistry, 82152 Martinsried, Germany.
Eicke LatzInstitute of Innate Immunity, University Hospital Bonn, 53127 Bonn, Germany; Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA; German Center for Neurodegenerative Diseases, 53175 Bonn, Germany. Electronic address: eicke.latz@uni-bonn.de.
University Hospital Bonn · DEHelmholtz Centre for Infection Research · DEBroad Institute · USCenter for Cancer Research · USMax Planck Institute of Biochemistry · DESystems Biology Institute · JPUniversity of Bonn · DEUniversity of Massachusetts Chan Medical School · USWhitehead Institute for Biomedical Research · US

Funding

Distinct Functional Outcomes of BCR/TLR7 and BCR/TLR9 Co-engagementR01AR066808 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MARSHAK-ROTHSTEIN, ANN · 2015 to 2019
$2.6M
NIAMS NIH HHS R01 AR066808
6 · The paper itself

Abstract

Unc-93 homolog B1 (UNC93B1) is a key regulator of nucleic acid (NA)-sensing Toll-like receptors (TLRs). Loss of NA-sensing TLR responses in UNC93B1-deficient patients facilitates Herpes simplex virus type 1 (HSV-1) encephalitis. UNC93B1 is thought to guide NA-sensing TLRs from the endoplasmic reticulum (ER) to their respective endosomal signaling compartments and to guide the flagellin receptor TLR5 to the cell surface, raising the question of how UNC93B1 mediates differential TLR trafficking. Here, we report that UNC93B1 regulates a step upstream of the differential TLR trafficking process. We discovered that UNC93B1 deficiency resulted in near-complete loss of TLR3 and TLR7 proteins in primary splenic mouse dendritic cells and macrophages, showing that UNC93B1 is critical for maintaining TLR expression. Notably, expression of an ER-retained UNC93B1 version was sufficient to stabilize TLRs and largely restore endosomal TLR trafficking and activity. These data are critical for an understanding of how UNC93B1 can regulate the function of a broad subset of TLRs.

Indexed as

AnimalsDendritic CellsEndoplasmic ReticulumEndosomesHEK293 CellsHumansMacrophagesMembrane Transport ProteinsMice, Inbred C57BLMice, KnockoutMolecular ChaperonesProtein StabilityProtein TransportSignal TransductionTHP-1 CellsToll-Like ReceptorsMembrane Transport ProteinsMolecular ChaperonesToll-Like ReceptorsUNC93B1 protein, mousenucleic acid sensingTLRTLR13TLR3TLR7TLR8TLR9TLR traffickingToll-like receptorsUNC93BUNC93B1

Identifiers

PMID29768176
PMCPMC6482051
OpenAlexW2804475258

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.