ArticleImmunity2018
Tissue Damage Signaling Is a Prerequisite for Protective Neutrophil Recruitment to Microbial Infection in Zebrafish.
Article in Immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Mechanotransduction by nuclear envelope tension.Nucleus (Austin, Tex.) · 2026Review
- Real-time characterisation of microbe-induced inflammation using a novel zebrafish larval corneal injury and infection model.Communications biology · 2026Article
- Zebrafish macrophages convert physical wound signals into rapid vascular permeabilization.Nature communications · 2026Article
- Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice.FEBS letters · 2025Article
- Exploring Immune Redox Modulation in Bacterial Infections: Insights into Thioredoxin-Mediated Interactions and Implications for Understanding Host-Pathogen Dynamics.Antioxidants (Basel, Switzerland) · 2024Review
- Oxoeicosanoid signaling mediates early antimicrobial defense in zebrafish.Cell reports · 2023Article
- Tumor regionalization after surgery: Roles of the tumor microenvironment and neutrophil extracellular traps.Experimental & molecular medicine · 2022Review
- The yellow brick road to nuclear membrane mechanotransduction.APL bioengineering · 2022Review
- Components and Mechanisms of Nuclear Mechanotransduction.Annual review of cell and developmental biology · 2021Review
- Myeloid-derived growth factor regulates neutrophil motility in interstitial tissue damage.The Journal of cell biology · 2021Article
- Modulating the Inflammatory Response to Wounds and Cancer Through Infection.Frontiers in cell and developmental biology · 2021Article
- The effects of neutrophil-generated hypochlorous acid and other hypohalous acids on host and pathogens.Cellular and molecular life sciences : CMLS · 2021Review
- Disease Mechanisms of Perioperative Organ Injury.Anesthesia and analgesia · 2020Review
- Distinct Tissue Damage and Microbial Cues Drive Neutrophil and Macrophage Recruitment to Thermal Injury.iScience · 2020Article
- An in vivo brain-bacteria interface: the developing brain as a key regulator of innate immunity.NPJ Regenerative medicine · 2020Article
- Pressure regulates immune-cell function.Nature · 2019Article
- Zebrafish in Inflammasome Research.Cells · 2019Review
- Live imaging of leukocyte recruitment in a zebrafish model of chemical liver injury.Scientific reports · 2019Article
- High-Affinity Bent βCell reports · 2019Article
- Commensal Microbiota Regulate Vertebrate Innate Immunity-Insights From the Zebrafish.Frontiers in immunology · 2019Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Tissue damage and infection are deemed likewise triggers of innate immune responses. But whereas neutrophil responses to microbes are generally protective, neutrophil recruitment into damaged tissues without infection is deleterious. Why neutrophils respond to tissue damage and not just to microbes is unknown. Is it a flaw of the innate immune system that persists because evolution did not select against it, or does it provide a selective advantage? Here we dissect the contribution of tissue damage signaling to antimicrobial immune responses in a live vertebrate. By intravital imaging of zebrafish larvae, a powerful model for innate immunity, we show that prevention of tissue damage signaling upon microbial ear infection abrogates leukocyte chemotaxis and reduces animal survival, at least in part, through suppression of cytosolic phospholipase A
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.