ArticleThe New England journal of medicine2018
Balanced Crystalloids versus Saline in Critically Ill Adults.
Registry-linked trialAbstract readLetterComment
In one paragraph
Article in The New England journal of medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03654001 (Efficacy of Albumin Replacement and Balanced Solution in Patients With Septic Shock), which is not on this map. Cited by 37 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 4 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Albumin Replacement and Balanced Solution in Patients With Septic Shock (the ALBIOSS-BALANCED Trial): a 2-by-2 Factorial, Investigator-initiated, Open- Label, Multicenter, Randomized, Controlled Trial
Who cites it
37 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- [S3 guideline on sepsis-prevention, diagnosis, therapy, and follow-up care-update 2025].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025Guideline
- European Society of Intensive Care Medicine clinical practice guideline on fluid therapy in adult critically ill patients. Part 1: the choice of resuscitation fluids.Intensive care medicine · 2024Guideline
- Physical and Chemical Compatibility of Medications Commonly Used in Critically Ill Patients With Balanced Crystalloids: A Systematic Review.The Annals of pharmacotherapy · 2024Pooled it
- Acetate- versus lactate-buffered crystalloid solutions: A systematic review with meta-analysis and trial sequential analysis.Acta anaesthesiologica Scandinavica · 2022Pooled it
- Balanced Crystalloids versus Saline in Critically Ill Adults with Hyperkalemia or Acute Kidney Injury: Secondary Analysis of a Clinical Trial.American journal of respiratory and critical care medicine · 2021Trial
- Development and external validation of a prediction model for major adverse kidney events within 30 days in sepsis associated acute kidney injury: a multi-center retrospective clinical study.BMC medical informatics and decision making · 2026Article
- Article
- Chronic Kidney Disease Is a Risk Factor for the Development of Hyperchloremic Metabolic Acidosis After Repeated Therapeutic Plasma Exchanges.Journal of clinical apheresis · 2025Article
- Preoperative myosteatosis and perioperative serum chloride levels predict 180 day major complications after radical cystectomy.Scientific reports · 2025Article
- Changing the culture of chaos.Acta anaesthesiologica Scandinavica · 2025Article
- Management of diabetic keto-acidosis in adult patients admitted to intensive care unit: an ESICM-endorsed international survey.Critical care (London, England) · 2024Article
- Advancements in Trauma-Induced Acute Kidney Injury: Diagnostic and Therapeutic Innovations.Life (Basel, Switzerland) · 2024Review
- A severe pediatric life-threatening metabolic ketoacidosis.Journal of diabetes and metabolic disorders · 2024Article
- Perioperative Acute Kidney Injury: Implications, Approach, Prevention.Advances in anesthesia · 2023Review
- Article
- Electrolyte derangements in critically ill children receiving balanced versus unbalanced crystalloid fluid resuscitation.BMC nephrology · 2022Observational
- Hemodynamic management of acute brain injury caused by cerebrovascular diseases: a survey of the European Society of Intensive Care Medicine.Intensive care medicine experimental · 2022Article
- Colorectal Surgery in Critically Unwell Patients: A Multidisciplinary Approach.Clinics in colon and rectal surgery · 2022Review
- Pr-AKI: Acute Kidney Injury in Pregnancy - Etiology, Diagnostic Workup, Management.Geburtshilfe und Frauenheilkunde · 2022Article
- Perioperative Doppler measurements of renal perfusion are associated with acute kidney injury in patients undergoing cardiac surgery.Scientific reports · 2021Article
Corrections and comments
- Comment on
- Comment on
- Comment on
- Comment on
Authors and funding
3 authors.
Matthew W SemlerVanderbilt University Medical Center, Nashville, TN
Wesley H SelfVanderbilt University Medical Center, Nashville, TN
Todd W RiceVanderbilt University Medical Center, Nashville, TN
Funding
Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7MThe Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MClinical and Translational Training Program in Pulmonary MedicineT32HL087738 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lorraine B Ware · 2007 to 2026
$7.0MAltering Sedation Paradigms to Improve Brain Injury and Survival in Severe SepsisR01HL111111 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PANDHARIPANDE, PRATIK · 2012 to 2017
$3.7MThe Vanderbilt Emergency Medicine Research Training Program (VEMRT)K12HL109019 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COLLINS, SEAN PATRICK, STORROW, ALAN B · 2011 to 2015
$3.7MThe INSIGHT-ICU Study: Illuminating Neuropsychological dysfunction and Systemic Inflammatory mechanisms Gleaned after Hospitalization in Trauma-ICU StudyR01GM120484 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PATEL, MAYUR B · 2017 to 2021
$3.0MThe Vanderbilt Emergency Care Research Training ProgramK12HL133117 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STORROW, ALAN B · 2016 to 2020
$1.9MSerial, non-invasive molecular analysis of exhaled breath condensate to define the pulmonary flora in critically injured, ventilated adultsR01GM115353 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DRAKE, WONDER P., MAY, ADDISON K · 2015 to 2020
$1.4MCitrulline to Prevent or Mitigate Acute Lung Injury in Severe SepsisR34HL105869 · NHLBI · VANDERBILT UNIVERSITY · PI RICE, TODD W · 2012 to 2014
$686kSalivary Cortisol as a Marker of Community-Acquired Pneumonia Severity in AdultsK23GM110469 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SELF, WESLEY H · 2015 to 2018
$683kRole of Endothelial and Brain Injury in Acute and Long-term Brain DysfunctionR03AG045085 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HUGHES, CHRISTOPHER · 2014 to 2015
$232kNCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002243NHLBI NIH HHS K12 HL109019NHLBI NIH HHS K12 HL133117NHLBI NIH HHS R01 HL111111NHLBI NIH HHS R34 HL105869NHLBI NIH HHS T32 HL087738NIA NIH HHS R03 AG045085NIGMS NIH HHS K23 GM110469NIGMS NIH HHS R01 GM115353NIGMS NIH HHS R01 GM120484
Abstract
PubMed holds no abstract for this paper.
Indexed as
Critical IllnessIsotonic SolutionsAdultColloidsCrystalloid SolutionsFluid TherapyHumansSodium ChlorideColloidsCrystalloid SolutionsIsotonic SolutionsSodium Chloride
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT03654001ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.