Evidence map›Paper›PMID 29768045›Full record

ArticleAmerican journal of physiology. Cell physiology2018

MFe

Merla J Hubler, Keith M Erikson, Arion J Kennedy, Alyssa H Hasty

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 42 citations in OpenAlex.

  1. Observational
  2. Review
  3. Adipose-Tissue Macrophage Diversity and Functions.International journal of molecular sciences · 2026
    Review
  4. Review
  5. Article
  6. Review
  7. Iron and the immune system.Nature reviews. Immunology · 2025
    Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. White adipose tissue mitochondrial bioenergetics in metabolic diseases.Reviews in endocrine & metabolic disorders · 2023
    Review
  15. Metaflammation in obesity and its therapeutic targeting.Science translational medicine · 2023
    Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Merla J HublerDepartment of Molecular Physiology and Biophysics, School of Medicine, Vanderbilt University , Nashville, Tennessee.
Keith M EriksonDepartment of Nutrition, University of North Carolina at Greensboro , Greensboro, North Carolina.
Arion J KennedyDepartment of Molecular Physiology and Biophysics, School of Medicine, Vanderbilt University , Nashville, Tennessee.
Alyssa H HastyDepartment of Molecular Physiology and Biophysics, School of Medicine, Vanderbilt University , Nashville, Tennessee.ORCID 0000-0001-7302-8045
Vanderbilt University · USUniversity of North Carolina at Greensboro · US

Funding

Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
The Role of CD8+ T Cells In The Development of Nonalcoholic Fatty Liver DiseaseK01HL121010 · NHLBI · VANDERBILT UNIVERSITY · PI KENNEDY, ARION · 2014 to 2018
$565k
Elucidating the role of iron metabolizing macrophages in adipose tissueF30DK103438 · NIDDK · VANDERBILT UNIVERSITY · PI HUBLER, MERLA J. · 2014 to 2017
$132k
BLRD VA I01 BX002195NHLBI NIH HHS K01 HL121010NIDDK NIH HHS F30 DK103438NIDDK NIH HHS P30 DK058404NIGMS NIH HHS T32 GM007347
6 · The paper itself

Abstract

Resident adipose tissue macrophages (ATMs) play multiple roles to maintain tissue homeostasis, such as removing excess free fatty acids and regulation of the extracellular matrix. The phagocytic nature and oxidative resiliency of macrophages not only allows them to function as innate immune cells but also to respond to specific tissue needs, such as iron homeostasis. MFe

Indexed as

AdipocytesAdipose TissueAnimalsCell LineDietary SupplementsInflammationIron, DietaryIron OverloadMacrophagesMaleMiceMice, Inbred C57BLMonocytesIron, Dietaryadiposehomeostasisironmacrophagepolarization

Identifiers

PMID29768045
PMCPMC6171041
OpenAlexW2804027879

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.