ArticleNano letters2018
Detection of Sub-fM DNA with Target Recycling and Self-Assembly Amplification on Graphene Field-Effect Biosensors.
Article in Nano letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Who cites it
31 citing papers in PubMed, 103 citations in OpenAlex.
- Acceleration of DNA reactions on the algae-based microrobots.Journal of nanobiotechnology · 2026Article
- Mechanism and kinetics of reactive yellow 145 decolorization by catalytic nano zero-valent iron particles.Scientific reports · 2026Article
- A Suspended Graphene Field-Effect Transistor for Ultra-Sensitive and Label-Free Detection of Cancer Biomarker miR-21.Biosensors · 2026Article
- Future perspectives of GMO detection in agriculture: strategies for electrochemical nucleic acid detection.Mikrochimica acta · 2025Review
- Advanced Materials for Biological Field-Effect Transistors (Bio-FETs) in Precision Healthcare and Biosensing.Advanced healthcare materials · 2025Review
- Graphene Biosensor Differentiating Sensitive Interactions between Ribonucleic Acid and Dipeptide Repeats in Liquid-Liquid Phase Separation.ACS applied materials & interfaces · 2025Article
- Flexible Graphene Field-Effect Transistors and Their Application in Flexible Biomedical Sensing.Nano-micro letters · 2024Review
- Minimizing Contact Resistance and Flicker Noise in Micro Graphene Hall Sensors Using Persistent Carbene Modified Gold Electrodes.ACS applied materials & interfaces · 2024Article
- Interplay of graphene-DNA interactions: Unveiling sensing potential of graphene materials.Applied physics reviews · 2024Article
- Label-free detection of synthetic, full genomic length HIV-1 RNA at the few-copy level.Sensors and actuators. B, Chemical · 2023Article
- Graphene Sensor Arrays for Rapid and Accurate Detection of Pancreatic Cancer Exosomes in Patients' Blood Plasma Samples.ACS nano · 2023Article
- Exchange Coupling Effects on the Magnetotransport Properties of Ni-Nanoparticle-Decorated Graphene.Nanomaterials (Basel, Switzerland) · 2023Article
- Review on two-dimensional material-based field-effect transistor biosensors: accomplishments, mechanisms, and perspectives.Journal of nanobiotechnology · 2023Review
- High-intensity vector signals for detecting SARS-CoV-2 RNA using CRISPR/Cas13a couple with stabilized graphene field-effect transistor.Biosensors & bioelectronics · 2023Article
- Graphene-Based Field-Effect Transistors in Biosensing and Neural Interfacing Applications: Recent Advances and Prospects.Analytical chemistry · 2023Review
- Polyethylene Glycol Functionalized Silicon Nanowire Field-Effect Transistor Biosensor for Glucose Detection.Nanomaterials (Basel, Switzerland) · 2023Article
- Highly stable integration of graphene Hall sensors on a microfluidic platform for magnetic sensing in whole blood.Microsystems & nanoengineering · 2023Article
- Nucleotide detection mechanism and comparison based on low-dimensional materials: A review.Frontiers in bioengineering and biotechnology · 2023Review
- Fabrication and Functionalisation of Nanocarbon-Based Field-Effect Transistor Biosensors.Chembiochem : a European journal of chemical biology · 2022Review
- Graphene-Based Ion-Selective Field-Effect Transistor for Sodium Sensing.Nanomaterials (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
All-electronic DNA biosensors based on graphene field-effect transistors (GFETs) offer the prospect of simple and cost-effective diagnostics. For GFET sensors based on complementary probe DNA, the sensitivity is limited by the binding affinity of the target oligonucleotide, in the nM range for 20 mer targets. We report a ∼20 000× improvement in sensitivity through the use of engineered hairpin probe DNA that allows for target recycling and hybridization chain reaction. This enables detection of 21 mer target DNA at sub-fM concentration and provides superior specificity against single-base mismatched oligomers. The work is based on a scalable fabrication process for biosensor arrays that is suitable for multiplexed detection. This approach overcomes the binding-affinity-dependent sensitivity of nucleic acid biosensors and offers a pathway toward multiplexed and label-free nucleic acid testing with high accuracy and selectivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.