Evidence map›Paper›PMID 29767950›Full record

ArticleACS chemical biology2018

Different Benzodiazepines Bind with Distinct Binding Modes to GABA

Alshaimaa A Elgarf, David C B Siebert, Friederike Steudle, Angelika Draxler, Guanguan Li, Shengming Huang, James M Cook, Margot Ernst, Petra Scholze

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in ACS chemical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06357104 (Detoxification From the Lipid Tract by Cocktail Design), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06357104 phase4completednot on this mapstarted 2024, after this paper: background citation

Detoxification From the Lipid Tract by Cocktail Design

TypeinterventionalSponsorPachankis, Yang I., M.D.Ran2024 to 2024Enrolled1ConditionsCOVID-19 Vaccine Adverse ReactionArmselectroencephalogram biofeedback, electrical brain stimulation, ultra-low frequency transcranial magnetic stimulation, Sertraline Hydrochloride, Clonazepam
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. In vitro γ-aminobutyric acid A (GABACommunications chemistry · 2026
    Article
  3. Article
  4. Modular Structure and Polymerization Status of GABAInternational journal of molecular sciences · 2024
    Article
  5. Development of non-sedating benzodiazepines withAntimicrobial agents and chemotherapy · 2024
    Article
  6. Article
  7. Development of non-sedating antischistosomal benzodiazepines.bioRxiv : the preprint server for biology · 2024
    Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. COVID-19 Therapeutics: Use, Mechanism of Action, and Toxicity (Xenobiotics).Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2023
    Review
  13. GABAInternational journal of molecular sciences · 2022
    Article
  14. Aromas Influencing the GABAergic System.Molecules (Basel, Switzerland) · 2022
    Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Alshaimaa A ElgarfDepartment of Pathobiology of the Nervous System, Center for Brain Research , Medical University of Vienna , 1090 Vienna , Austria.
David C B SiebertInstitute of Applied Synthetic Chemistry , TU Wien , 1060 Vienna , Austria.ORCID 0000-0002-7132-9765
Friederike SteudleDepartment of Pathobiology of the Nervous System, Center for Brain Research , Medical University of Vienna , 1090 Vienna , Austria.
Angelika DraxlerDepartment of Molecular Neurosciences, Center for Brain Research , Medical University of Vienna , 1090 Vienna , Austria.
Guanguan LiDepartment of Chemistry and Biochemistry , University of Wisconsin-Milwaukee , Milwaukee , Wisconsin 53211 , United States.
Shengming HuangDepartment of Chemistry and Biochemistry , University of Wisconsin-Milwaukee , Milwaukee , Wisconsin 53211 , United States.
James M CookDepartment of Chemistry and Biochemistry , University of Wisconsin-Milwaukee , Milwaukee , Wisconsin 53211 , United States.ORCID 0000-0001-5512-3022
Margot ErnstDepartment of Molecular Neurosciences, Center for Brain Research , Medical University of Vienna , 1090 Vienna , Austria.
Petra ScholzeDepartment of Pathobiology of the Nervous System, Center for Brain Research , Medical University of Vienna , 1090 Vienna , Austria.ORCID 0000-0003-4984-6034
Medical University of Vienna · ATUniversity of Wisconsin–Milwaukee · USAin Shams University · EGTU Wien · AT

Funding

Development of new drugs for asthma by targeting GABA(A) receptors in the lungR01HL118561 · NHLBI · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2014 to 2017
$2.0M
Design of New Therapeutic Agents to Treat SchizophreniaR01MH096463 · NIMH · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2013 to 2017
$1.9M
Synthesis of Alpha2/Alpha3 GABA Agonists to Treat Neuropathic PainR01NS076517 · NINDS · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2012 to 2015
$1.3M
Austrian Science Fund FWF W 1232NHLBI NIH HHS R01 HL118561NIMH NIH HHS R01 MH096463NINDS NIH HHS R01 NS076517
6 · The paper itself

Abstract

Benzodiazepines are clinically relevant drugs that bind to GABA

Indexed as

AnimalsBenzodiazepinesBinding SitesHumansLigandsMolecular Docking SimulationMolecular StructureRatsReceptors, GABA-AStereoisomerismTriazolesTritiumBenzodiazepinesLigandsReceptors, GABA-ATriazolesTritium

Identifiers

PMID29767950
PMCPMC6102643
OpenAlexW2804047470

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.