ArticleBritish journal of haematology2018
Risk factors for vitamin D deficiency in sickle cell disease.
Article in British journal of haematology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Safety and efficacy of monthly high-dose vitamin DEuropean journal of pediatrics · 2024Trial
- The impact of vitamin D supplementation on VDR gene expression and body composition in monozygotic twins: randomized controlled trial.Scientific reports · 2020Trial
- Vitamin D Supplementation Improves Health-Related Quality of Life and Physical Performance in Children with Sickle Cell Disease and in Healthy Children.Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & PractitionersTrial
- Article
- Vitamin D deficiency in sickle cell disease: a neglected comorbidity in Tunisia.Annals of hematology · 2026Article
- Vitamin D Deficiency and Its Hematological Correlates in Patients with Sickle Cell Disease at a Ugandan Clinic.Journal of blood medicine · 2026Article
- Dysregulated vitamin D signaling in Hashimoto's thyroiditis: an integrated transcriptomic study in a Korean cohort.Frontiers in endocrinology · 2025Observational
- Society for Maternal-Fetal Medicine Consult Series #68: Sickle cell disease in pregnancy.American journal of obstetrics and gynecology · 2024Article
- Effects of Vitamin D Deficiency on Sepsis.Nutrients · 2023Article
- Gene expression changes in sickle cell reticulocytes and their clinical associations.Scientific reports · 2023Article
- Impact of Vitamin D Supplementation on the Clinical Outcomes and Epigenetic Markers in Patients with Acute Coronary Syndrome.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Perspectives: on Precision Nutrition Research in Heart, Lung, and Blood Diseases and Sleep Disorders.Advances in nutrition (Bethesda, Md.) · 2022Article
- Primary Hyperparathyroidism in Homozygous Sickle Cell Patients: A Hemolysis-Mediated Hypocalciuric Hypercalcemia Phenotype?Journal of clinical medicine · 2021Article
- Vitamin D level, lipid profile, and vitamin D receptor and transporter gene variants in sickle cell disease patients from Kurdistan of Iraq.Journal of clinical laboratory analysis · 2021Article
- Novel biomarker for predicting sepsis mortality: vitamin D receptor.The Journal of international medical research · 2021Observational
- Mechanisms of Bone Impairment in Sickle Bone Disease.International journal of environmental research and public health · 2021Review
- Development of Algorithm for Clinical Management of Sickle Cell Bone Disease: Evidence for a Role of Vertebral Fractures in Patient Follow-up.Journal of clinical medicine · 2020Article
- Vitamin D and Nonskeletal Complications among Egyptian Sickle Cell Disease Patients.Advances in hematology · 2018Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Vitamin D deficiency (VDD), 25-OHD levels <20 ng/ml, is prevalent among patients with sickle cell disease (SCD) and is linked to acute and chronic pain and bone fracture in this population. There is limited literature regarding VDD-associated risk factors for SCD. We examined potential clinical and genomic parameters associated with VDD in 335 adults with SCD in a cross-sectional study. VDD was present in 65% of adult SCD patients, and 25-OHD levels independently and positively correlated with older age (P < 0·001) and vitamin D supplementation (P < 0·001). 25-OHD levels were higher in SCD patients over 40 years of age compared to the general African-American population. Both lower 25-OHD levels and increased pain frequency were associated with increased expression of SLC6A5 encoding glycine transporter-2 (GlyT2), a protein involved in neuronal pain pathways. Lower 25-OHD levels were also associated with increased expression of CYP3A4, and with decreased expression of GC (also termed DBP) and VDR, three genes involved in vitamin D metabolism. We conclude that vitamin D supplementation should be an almost universal feature of the care of young adults with SCD, and that further research is warranted into genomic factors that regulate vitamin D metabolism in SCD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.