ArticleBritish journal of haematology2018
Comorbidities associated with higher von Willebrand factor (VWF) levels may explain the age-related increase of VWF in von Willebrand disease.
Article in British journal of haematology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03521583 (Von Willebrand Disease in the Netherlands - Prospective Study), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Von Willebrand Disease in the Netherlands - Prospective Study (WiN-Pro)
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- von Willebrand factor levels in the diagnosis of von Willebrand disease: a systematic review and meta-analysis.Blood advances · 2022Pooled it
- Population Frequencies of VWD-Associated Genotypes: Cross-Resource Evidence from RGC-ME and gnomAD.International journal of molecular sciences · 2026Article
- Early Postoperative Changes in Von Willebrand Factor Activity Are Associated With Future Bleeding and Stroke in HeartMate 3 Patients.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2025Article
- Von Willebrand Factor Activity Association With Outcomes After Transcatheter Edge-to-Edge Mitral Valve Repair.JACC. Advances · 2024Article
- Type 1 VWD classification revisited: novel insights from combined analysis of the LoVIC and WiN studies.Blood · 2024Article
- Von Willebrand factor targeted thrombolysis in canine basilar artery occlusion.Frontiers in neurology · 2024Article
- Phenotypic and genotypic (exon 28) characterization of patients diagnosed with von Willebrand disease type 1 in Eastern Saudi Arabia.Journal of medicine and life · 2023Article
- Von Willebrand Disease Epidemiology, Burden of Illness and Management: A Systematic Review.Journal of blood medicine · 2023Review
- Diagnostic pitfalls and conundrums in type 1 von Willebrand disease.Hematology. American Society of Hematology. Education Program · 2022Article
- How to manage bleeding disorders in aging patients needing surgery.Hematology. American Society of Hematology. Education Program · 2021Article
- Age-Associated Increase in Thrombogenicity and Its Correlation with von Willebrand Factor.Journal of clinical medicine · 2021Review
- Unraveling von Willebrand factor deficiency.Blood · 2021Article
- Population pharmacokinetics of the von Willebrand factor-factor VIII interaction in patients with von Willebrand disease.Blood advances · 2021Article
- Von Willebrand Factor Multimer Densitometric Analysis: Validation of the Clinical Accuracy and Clinical Implications in Von Willebrand Disease.HemaSphere · 2021Article
- Major differences in clinical presentation, diagnosis and management of men and women with autosomal inherited bleeding disorders.EClinicalMedicine · 2021Article
- Low VWF: insights into pathogenesis, diagnosis, and clinical management.Blood advances · 2020Review
- One piece of the puzzle: Population pharmacokinetics of FVIII during perioperative Haemate PJournal of thrombosis and haemostasis : JTH · 2020Article
- von Willebrand factor and factor VIII levels after desmopressin are associated with bleeding phenotype in type 1 VWD.Blood advances · 2019Article
- Case-based discussion on the implications of exogenous estrogens in hemostasis and thrombosis: the hematologist's view.Hematology. American Society of Hematology. Education Program · 2019Article
- BMI is an important determinant of VWF and FVIII levels and bleeding phenotype in patients with von Willebrand disease.American journal of hematology · 2019Article
Corrections and comments
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Authors and funding
15 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Some comorbidities, such as hypertension, are associated with higher von Willebrand factor (VWF) levels in the general population. No studies have been conducted to assess this association in patients with von Willebrand disease (VWD). Therefore, we studied this association in patients with type 1 (n = 333) and type 2 (n = 203) VWD from the 'WiN" study. VWF antigen (VWF:Ag) was higher in type 1 VWD patients with hypertension [difference: 0·23 iu/ml, 95% confidence interval (CI): 0·11-0·35], diabetes mellitus (0·11 iu/ml, 95% CI: -0·02 to 0·23), cancer (0·14 iu/ml, 95% CI: 0·03-0·25) and thyroid dysfunction (0·14 iu/ml, 95% CI: 0·03-0·26) than in patients without these comorbidities (all corrected for age, sex and blood group). Similar results were observed for VWF collagen binding capacity (VWF:CB), VWF activity as measured by the VWF monoclonal antibody assay (VWF:Ab) and factor VIII (FVIII) coagulant activity (FVIII:C). In type 1 VWD, age was associated with higher VWF:Ag (0·03 iu/ml; 95% CI: 0·01-0·04), VWF:CB (0·02 iu/ml; 95% CI: 0·00-0·04), VWF:Ab (0·04 iu/ml; 95% CI: 0·02-0·06) and FVIII:C (0·03 iu/ml; 95% CI: 0·01-0·06) per decade increase. After adjustment for relevant comorbidities, these associations were no longer significant. Despite the higher VWF and FVIII levels, type 1 VWD patients with comorbidities had more bleeding episodes, particularly during surgery. There was no association between comorbidities and VWF/FVIII levels or bleeding phenotype in type 2 VWD patients. In conclusion, comorbidities are associated with higher VWF and FVIII levels in type 1 VWD and may explain the age-related increase of VWF and FVIII levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.