Evidence map›Paper›PMID 29767690›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2019

Entorhinal Cortex Volume Is Associated With Dual-Task Gait Cost Among Older Adults With MCI: Results From the Gait and Brain Study.

Ryota Sakurai, Robert Bartha, Manuel Montero-Odasso

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03020381 (Gait as Predictor of Cognitive Decline, Dementia, and Risk of Falls in MCI. A Cohort Study), which is not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03020381 recruitingnot on this map

Gait as Predictor of Cognitive Decline, Dementia, and Risk of Falls in MCI. A Cohort Study

TypeobservationalSponsorManuel Montero OdassoRan2007 to 2033Enrolled600ConditionsGait Apraxia, Mild Cognitive Impairment, Subjective Cognitive Impairment, Cerebral Atrophy
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.

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  18. Deep Neural Network-Based Video Processing to Obtain Dual-Task Upper-Extremity Motor Performance Toward Assessment of Cognitive and Motor Function.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Ryota SakuraiGait and Brain Lab, Parkwood Institute, Lawson Health Research Institute, London, Ontario, Canada.
Robert BarthaCenter for Functional and Metabolic Mapping, Robarts Research Institute, London, Canada.
Manuel Montero-OdassoGait and Brain Lab, Parkwood Institute, Lawson Health Research Institute, London, Ontario, Canada.
Lawson Health Research Institute · CAWestern University · CA

Funding

CIHR PJT 153100
6 · The paper itself

Abstract

backgroundLow dual-task gait performance (the slowing of gait speed while performing a demanding cognitive task) is associated with low cognitive performance and an increased risk of progression to dementia in older adults with mild cognitive impairment. However, the reason for this remains unclear. This study aimed to examine the relationship between dual-task cost and regional brain volume, focusing on the hippocampus, parahippocampal gyrus, entorhinal cortex, and motor and lateral frontal cortices in older adults with mild cognitive impairment.

methodsForty older adults with mild cognitive impairment from the "Gait and Brain Study" were included in this study. Gait velocity was measured during single-task (ie, walking alone) and dual-task (ie, counting backwards, subtracting serial sevens, and naming animals, in addition to walking) conditions, using an electronic walkway. Regional brain volumes were derived by automated segmentation, using 3T magnetic resonance imaging.

resultsPartial rank correlation analyses demonstrated that a smaller volume of the left entorhinal cortex was associated with higher dual-task costs in counting backwards and subtracting serial sevens conditions. Subsequent logistic regression analyses demonstrated that a smaller volume of the left entorhinal cortex was independently associated with higher dual-task cost (slowing down >20% when performing cognitive task) in these two conditions. There were no other significant associations.

conclusionsOur results show that lower dual-task gait performance is associated with volume reduction in the entorhinal cortex. Cognitive and motor dysfunction in older adults with mild cognitive impairment may reflect a shared pathogenic mechanism, and dual-task-related gait changes might be a surrogate motor marker for Alzheimer's disease pathology.

Indexed as

AgedCognitive DysfunctionDisease ProgressionEntorhinal CortexFemaleGait Disorders, NeurologicHumansMagnetic Resonance ImagingMaleNeuropsychological TestsOrgan SizeTask Performance and AnalysisDual taskEntorhinal cortexGaitHippocampus

Identifiers

PMID29767690
PMCPMC6477635
OpenAlexW2803155711

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.