Evidence map›Paper›PMID 29767637›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2018

HIV Risk Among Adolescent Girls and Young Women in Age-Disparate Partnerships: Evidence From KwaZulu-Natal, South Africa.

Brendan Maughan-Brown, Gavin George, Sean Beckett, Meredith Evans, Lara Lewis, Cherie Cawood, David Khanyile, Ayesha B M Kharsany

Open access · greenAbstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Pooled it
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  4. Human Immunodeficiency Virus (HIV)-1 Transmission Among Persons With Acute HIV-1 Infection in Malawi: Demographic, Behavioral, and Phylogenetic Relationships.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019
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  18. Sexual partnership concurrency and age disparities associated with sexually transmitted infection and risk behavior in rural communities in Kenya and Uganda.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Brendan Maughan-BrownSouthern Africa Labour and Development Research Unit (SALDRU), University of Cape Town, Cape Town, South Africa.
Gavin GeorgeHealth Economics and HIV and AIDS Research Division (HEARD), University of KwaZulu-Natal, Durban, South Africa.
Sean BeckettHealth Economics and HIV and AIDS Research Division (HEARD), University of KwaZulu-Natal, Durban, South Africa.
Meredith EvansDepartment of Anthropology, York University, Toronto, Canada.
Lara LewisCenter for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, South Africa, and.
Cherie CawoodEpicenter AIDS Risk Management (Pty) Limited, South Africa.
David KhanyileEpicenter AIDS Risk Management (Pty) Limited, South Africa.
Ayesha B M KharsanyCenter for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, South Africa, and.
Centre for the AIDS Programme of Research in South Africa · ZAUniversity of KwaZulu-Natal · ZAUniversity of Cape Town · ZAYork University · CA

Funding

Identifying sources of HIV infection in adolescent girls in rural South AfricaR01HD083343 · NICHD · CENTRE/AIDS PROGRAMME/RES/SOUTH AFRICA · PI KHARSANY, AYESHA BM, KOHLER, HANS-PETER · 2015 to 2019
$1.7M
NICHD NIH HHS R01 HD083343
6 · The paper itself

Abstract

backgroundEvidence on the role of age-disparate partnerships in high HIV-infection rates among young women in sub-Saharan Africa remains inconclusive. This study examined the HIV-infection risk associated with age-disparate partnerships among 15- to 24-year-old women in a hyperendemic setting in South Africa.

methodsFace-to-face questionnaire, and laboratory HIV and viral load data were collected during 2014-2015 among a representative sample (15-49 years old) in KwaZulu-Natal. The association between age-disparate partnerships (age difference ≥5 years) and HIV status among 15- to 24-year-old women (N = 1459) was assessed using multiple logistic regression analyses. Data from the male sample on all on-going partnerships (N = 1229) involving 15- to 24-year-old women were used to assess whether young women's age-disparate male partners were more likely to have a viral load ≥1000 copies per milliliter, a marker of HIV-infection risk.

resultsWomen reporting an age disparity in any of their 3 most recent partnerships were more likely to test HIV positive compared to women with only age-similar partners [adjusted odds ratio (aOR): 1.58, 95% confidence interval (CI): 1.20 to 2.09, P < 0.01]. Among partnerships men reported with 15- to 24-year-old women, the age-disparate male partners were more likely to be HIV positive and have a viral load ≥1000 copies per milliliter (aOR: 2.05, 95% CI: 1.30 to 3.24, P < 0.01) compared with age-similar partners. Results were similar for each category of age disparity: partners 5-9 years older (aOR: 2.01, 95% CI: 1.18 to 3.43, P = 0.010) and those ≥10 years older (aOR: 2.17, 95% CI: 1.01-4.66, P = 0.048).

conclusionsResults indicate that age-disparate partnerships increase young women's HIV risk, although conclusive evidence was not ascertained. Interventions addressing risk from age-disparate sexual partnering, including expanding antiretroviral treatment among older partners, may help to reduce HIV incidence among young women.

Indexed as

Age FactorsSexual PartnersAdolescentAdultFemaleHIV InfectionsHumansIncidenceMaleMiddle AgedRisk FactorsSexual BehaviorSouth AfricaViral LoadYoung Adult

Identifiers

PMID29767637
PMCPMC5968825
OpenAlexW2793574184

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.