ArticlePersonalized medicine2016
Patient willingness to undergo efavirenz dose reduction based on pharmacogenetic testing.
Article in Personalized medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
aimAmong HIV-infected adults receiving efavirenz fixed-dose combination tablets, genotyping could guide efavirenz dose reduction but would require more pills.
methodsWe assessed willingness to dose reduce among 129 patients at an HIV primary care clinic in the southeastern USA.
resultsWhen told that switching from one pill to two or three pills "might make you feel a little better", 47% expressed definite or possible willingness. This decreased to 9% if there was "a small chance it might not control your HIV as well". Clinical variables were not associated with willingness.
conclusionMany patients receiving a fixed-dose combination tablet may be willing to take more pills in order to dose reduce, guided by genetic testing, but only if virologic control is not compromised.
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