ArticlePulmonary circulation
Right ventricular stroke work correlates with outcomes in pediatric pulmonary arterial hypertension.
Article in Pulmonary circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Right ventricular stroke work index in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: A retrospective observational study.Pulmonary circulation · 2024Article
- Factors leading to supranormal cardiac index in pediatric pulmonary hypertension patients treated with parenteral prostanoid therapy.Pulmonary circulation · 2023Article
- Parameter inference in a computational model of haemodynamics in pulmonary hypertension.Journal of the Royal Society, Interface · 2023Article
- Data-driven computational models of ventricular-arterial hemodynamics in pediatric pulmonary arterial hypertension.Frontiers in physiology · 2022Article
- Mechanics of right ventricular dysfunction in pulmonary arterial hypertension and heart failure with preserved ejection fraction.Cardiovascular diagnosis and therapy · 2020Review
- Multilevel and multifidelity uncertainty quantification for cardiovascular hemodynamics.Computer methods in applied mechanics and engineering · 2020Article
- Performance of preconditioned iterative linear solvers for cardiovascular simulations in rigid and deformable vessels.Computational mechanics · 2019Article
- Clinical Applications of Pressure-Volume Assessment in Congenital Heart Disease.Journal of the Society for Cardiovascular Angiography & InterventionsReview
- Interpretation of a new biomarker for the right ventricle introduced to evaluate the severity of pulmonary arterial hypertension.Pulmonary circulationArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Pulmonary arterial hypertension (PAH) is characterized by elevated pulmonary artery pressures (PAP) and pulmonary vascular resistance (PVR). Optimizing treatment strategies and timing for transplant remains challenging. Thus, a quantitative measure to predict disease progression would be greatly beneficial in treatment planning. We devised a novel method to assess right ventricular (RV) stroke work (RVSW) as a potential biomarker of the failing heart that correlates with clinical worsening. Pediatric patients with idiopathic PAH or PAH secondary to congenital heart disease who had serial, temporally matched cardiac catheterization and magnetic resonance imaging (MRI) data were included. RV and PA hemodynamics were numerically determined by using a lumped parameter (circuit analogy) model to create pressure-volume (P-V) loops. The model was tuned using optimization techniques to match MRI and catheterization derived RV volumes and pressures for each time point. RVSW was calculated from the corresponding P-V loop and indexed by ejection fraction and body surface area (RVSW
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