ReviewCurrent gastroenterology reports2018
Speculation as to why the Frequency of Eosinophilic Esophagitis Is Increasing.
Review in Current gastroenterology reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Oral and upper gastrointestinal Crohn's disease: new perspectives on pathogenesis and clinical management.Frontiers in cell and developmental biology · 2026Review
- [Eosinophilic esophagitis].Innere Medizin (Heidelberg, Germany) · 2025Review
- Allergic phenotype identified on allergen testing is associated with proton pump inhibitor nonresponse in eosinophilic esophagitis.Journal of gastroenterology and hepatology · 2024Article
- Eosinophilic esophagitis is associated with increased risk of later inflammatory bowel disease in a nationwide Swedish population cohort.United European gastroenterology journal · 2024Article
- Impact of environmental factors on the epidemiology of eosinophilic esophagitis in southwestern Europe (2007-2020).The journal of allergy and clinical immunology. Global · 2023Article
- Increasing incidence of eosinophilic esophagitis in Sweden: a nationwide population study.Esophagus : official journal of the Japan Esophageal Society · 2022Article
- Eosinophilic esophagitis-established facts and new horizons.Seminars in immunopathology · 2021Review
- Mortality in Eosinophilic Esophagitis - a nationwide, population-based matched cohort study from 2005 to 2017.Upsala journal of medical sciences · 2021Article
- Early Life Risk Factors in Pediatric EoE: Could We Prevent This Modern Disease?Frontiers in pediatrics · 2020Review
- Treatment-resistant eosinophilic oesophagitis successfully managed with tofacitinib.BMJ case reports · 2019Article
- Eosinophilic esophagitis: novel concepts regarding pathogenesis and clinical manifestations.Journal of gastroenterology · 2019Review
- Eosinophilic esophagitis: Current concepts in diagnosis and treatment.World journal of gastroenterology · 2019Review
- Gastroesophageal Reflux Disease and Eosinophilic Esophagitis.Gastroenterology & hepatology · 2019Article
- Eosinophilic Esophagitis: Review and Update.Frontiers in medicine · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewThe frequency of eosinophilic esophagitis (EoE), an immune/antigen-mediated disorder first described in 1993, has been increasing rapidly. The purpose of this review is to consider hypotheses proposed to explain this increase and to speculate on their validity. RECENT
findingsThe hygiene hypothesis attributes the rise of EoE to modern hygienic conditions resulting in fewer childhood infections with microbes that might have protected against allergy development. Microbial dysbiosis, a change in the microbiome's composition and diversity caused by a modern affluent lifestyle, also might contribute to allergic conditions. Environmental factors including modern chemicals contaminating crops, livestock treated with hormones and antibiotics, food additives and processing changes, and pollutants in the air and water conceivably might predispose to EoE. One intriguing hypothesis attributes increasing EoE to increasing use of acid-suppressive medications like proton pump inhibitors, which might prevent peptic digestion of food allergens, increase gastric permeability, and alter the microbiome to favor food allergy development. In a recent pediatric case-control study, use of acid suppressants in infancy was by far the single strongest risk factor identified for later development of EoE. It remains unclear which, if any, of the above factors underlies the rising frequency of EoE. These factors need not be mutually exclusive, and the cause of EoE may well be multifactorial.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.