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ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2018

Validity of the EQ-5D-5L and reference norms for the Spanish population.

Gimena Hernandez, Olatz Garin, Yolanda Pardo, Gemma Vilagut, Àngels Pont, Mónica Suárez, Montse Neira, Luís Rajmil, Inigo Gorostiza, Yolanda Ramallo-Fariña and 3 more

10 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 10 registered trials, which are not on this map. Cited by 132 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03991377 naunknown statusnot on this mapstarted 2019, after this paper: background citation

A Multicenter Phase II Rater-blinded Randomized Controlled Trial (RCT) to Compare Effectiveness of Eye Movement Desensitization Reprocessing Therapy (EMDR) vs Treatment as Usual (TAU) in First Episode Psychosis and History of Trauma.

TypeinterventionalSponsorParc de Salut MarRan2019 to 2024Enrolled71ConditionsPsychotic Episode, Psychological TraumaArmsEye movement desensitization and reprocessing therapy, Treatment as usual
NCT05482620 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Parallel-group, Randomized Controlled Trial to Test the Effectiveness of a Nordic Walking Program in Patients With Asthma

TypeinterventionalSponsorUniversidade da CoruñaRan2022 to 2024Enrolled114ConditionsAsthmaArmsNordic walking program, Educational sessions and usual care
NCT05571124 naunknown statusnot on this mapstarted 2023, after this paper: background citation

The Implementation of a Web-based Workplace Exercise Intervention in the Reduction of Spinal Pain in Sedentary Administrative Personnel: Protocol of a Mixed Methodology Study.

TypeinterventionalSponsorUniversitat de LleidaRan2023 to 2024Enrolled66ConditionsBack Pain, Sedentary BehaviorArmsTherapeutic Exercise Intervention
NCT05884424 nacompletednot on this mapstarted 2023, after this paper: background citation

Effectiveness and Cost-Effectiveness of Robot Therapy With the Paro Robot in People Living With Dementia: A Randomized Controlled Multicenter Clinical Trial

TypeinterventionalSponsorInstituto de Mayores y Servicios Sociales (IMSERSO)Ran2023 to 2023Enrolled123ConditionsDementia, Neurocognitive Disorders, Mild Cognitive ImpairmentArmsPARO Therapy Robot
NCT06226285 nacompletednot on this mapstarted 2024, after this paper: background citation

Quality of Life for Carers Through a Person-Centred Technological Solution

TypeinterventionalSponsorUniversidade da CoruñaRan2024 to 2025Enrolled62ConditionsInformal Caregivers, Quality of Life, Technology, Activities of Daily LivingArmsTechQoL4Carers Platform
NCT06372002 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Effectiveness and Cost-Effectiveness of of Cognitive Stimulation Therapy - Spain (CST-ES) in People Living With Dementia: A Randomized Controlled Multicenter Clinical Trial

TypeinterventionalSponsorInstituto de Mayores y Servicios Sociales (IMSERSO)Ran2023 to 2024Enrolled683ConditionsDementia, Neurocognitive Disorders, Mild Cognitive ImpairmentArmsCognitive Stimulation Therapy (CST)
NCT06492590 nacompletednot on this mapstarted 2025, after this paper: background citation

Assessing a Multicomponent Intervention to Improve Quality of Life in Individuals With Long COVID-19 (COVIDL/MIQoL): A Randomized Controlled Trial

TypeinterventionalSponsorConsorci Sanitari de TerrassaRan2025 to 2025Enrolled74ConditionsLong COVID-19ArmsMulticomponent intervention
NCT07060690 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Women-Centered Approach: Evaluating a Human-Supported Online Intervention for Depression. Study on Its Efficacy and the Metabolic Signature of Personalised Treatment Response

TypeinterventionalSponsorFrancesc Colom, PsyD, PhDRan2026 to 2027Enrolled120ConditionsDepression Symptoms, Depression - Major Depressive Disorder, Depressive DisorderArmsiCBT with human interaction, Psychoeducational videos
NCT07394712 narecruitingnot on this mapstarted 2025, after this paper: background citation

Comprehensive Maintenance Program: a Health Haven for COPD in Lleida.The NAPOLEON Project.

TypeinterventionalSponsorInstitut de Recerca Biomèdica de LleidaRan2025 to 2026Enrolled86ConditionsCOPD - Chronic Obstructive Pulmonary Disease, Pulmonary Rehabilitation, Randomised Controlled TrialArmsInterdisciplinary intervention
NCT07495254 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effectiveness of Combined Super Inductive System (SIS) Therapy With Therapeutic Physical Therapy Exercise and Health Education in Lateral Elbow Tendinopathy

TypeinterventionalSponsorUniversity of Vic - Central University of CataloniaRan2026 to 2028Enrolled224ConditionsLateral Epicondylitis (Tennis Elbow), Lateral Epicondylalgia, Lateral Elbow TendinopathyArmsSuper Inductive System (SIS), therapeutic dose, Super Inductive System (SIS), non-therapeutic dose (active placebo), Therapeutic Exercise Program, Health Education
3 · Its place in the literature

Who cites it

132 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Psychometric properties of the EQ-5D-5L: a systematic review of the literature.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021
    Pooled it
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  4. Efficacy of a brief psychological intervention for adolescents with recent suicide attempt: A randomized clinical trial.European psychiatry : the journal of the Association of European Psychiatrists · 2025
    Trial
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  13. Impact of lung cancer diagnosis on patient lifestyle and physical activity.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Observational
  14. Article
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72 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Gimena HernandezHealth Services Research Group, IMIM (Hospital del Mar Medical Research Institute), Doctor Aiguader, 88, 08003, Barcelona, Spain.
Olatz GarinHealth Services Research Group, IMIM (Hospital del Mar Medical Research Institute), Doctor Aiguader, 88, 08003, Barcelona, Spain. ogarin@imim.es.ORCID http://orcid.org/0000-0001-6193-0779
Yolanda PardoHealth Services Research Group, IMIM (Hospital del Mar Medical Research Institute), Doctor Aiguader, 88, 08003, Barcelona, Spain.
Gemma VilagutHealth Services Research Group, IMIM (Hospital del Mar Medical Research Institute), Doctor Aiguader, 88, 08003, Barcelona, Spain.
Àngels PontHealth Services Research Group, IMIM (Hospital del Mar Medical Research Institute), Doctor Aiguader, 88, 08003, Barcelona, Spain.
Mónica SuárezSubdirección General de Información Sanitaria e Innovación, Spanish Ministry of Health, Social Services and Equality, Madrid, Spain.
Montse NeiraSubdirección General de Información Sanitaria e Innovación, Spanish Ministry of Health, Social Services and Equality, Madrid, Spain.
Luís RajmilHealth Services Research Group, IMIM (Hospital del Mar Medical Research Institute), Doctor Aiguader, 88, 08003, Barcelona, Spain.
Inigo GorostizaUnidad de Investigación, Hospital Universitario Basurto - Osakidetza, Bilbao, Spain.
Yolanda Ramallo-FariñaRed de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), Madrid, Spain.
Juan CabasesDepartamento de Economía, Universidad Pública de Navarra, Pamplona, Spain.
Jordi AlonsoHealth Services Research Group, IMIM (Hospital del Mar Medical Research Institute), Doctor Aiguader, 88, 08003, Barcelona, Spain.
Montse FerrerHealth Services Research Group, IMIM (Hospital del Mar Medical Research Institute), Doctor Aiguader, 88, 08003, Barcelona, Spain. mferrer@imim.es.

Funding

Generalitat de Catalunya 2014 SGR 748Instituto de Salud Carlos III PI12/00772
6 · The paper itself

Abstract

BACKGROUND AND

objectiveThe EuroQol 5 dimensions 5 levels (EQ-5D-5L) is the new version of EQ-5D, developed to improve its discriminatory capacity. This study aims to evaluate the construct validity of the Spanish version and provide index and dimension population-based reference norms for the new EQ-5D-5L.

methodsData were obtained from the 2011/2012 Spanish National Health Survey, with a representative sample (n = 20,587) of non-institutionalized Spanish adults (≥ 18 years). The EQ-5D-5L index was calculated by using the Spanish value set. Construct validity was evaluated by comparing known groups with estimators obtained through regression models, adjusted by age and gender. Sampling weights were applied to restore the representativeness of the sample and to calculate the norms stratified by gender and age groups. We calculated the percentages and standard errors of dimensions, and the deciles, percentiles 5 and 95, means, and 95% confidence intervals of the health index.

resultsAll the hypotheses established a priori for known groups were confirmed (P < 0.001). The EQ-5D-5L index indicated worse health in groups with lower education level (from 0.94 to 0.87), higher number of chronic conditions (0.96-0.79), probable psychiatric disorder (0.94 vs 0.80), strong limitations (0.96-0.46), higher number of days of restriction (0.93-0.64) or confinement to bed (0.92-0.49), and hospitalized in the previous 12 months (0.92 vs 0.81).

conclusionsThe EQ-5D-5L is a valid instrument to measure perceived health in the Spanish-speaking population. The representative population-based norms provided here will help improve the interpretation of results obtained with the new EQ-5D-5L.

Indexed as

Health StatusAdultAgedAged, 80 and overChronic DiseaseFemaleHealth SurveysHispanic or LatinoHumansMaleMiddle AgedQuality of LifeYoung AdultEQ–5D–5LEuroQolHealth-related quality of lifeHealth statusQuestionnairesReference valuesUtilitiesValidity

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 4 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.