ArticleIntensive care medicine2018
Prevalence and risk factors related to haloperidol use for delirium in adult intensive care patients: the multinational AID-ICU inception cohort study.
Article in Intensive care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 5 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Haloperidol for the treatment of delirium in ICU patients: a systematic review and meta‑analysis.European journal of medical research · 2025Pooled it
- Haloperidol for the treatment of delirium in critically ill patients: an updated systematic review with meta-analysis and trial sequential analysis.Critical care (London, England) · 2023Pooled it
- Pooled it
- Pooled it
- The effectiveness of non-pharmacological interventions in reducing the incidence and duration of delirium in critically ill patients: a systematic review and meta-analysis.Intensive care medicine · 2019Pooled it
- Long-term outcomes with haloperidol versus placebo in acutely admitted adult ICU patients with delirium.Intensive care medicine · 2024Trial
- Haloperidol vs. placebo for the treatment of delirium in ICU patients: a pre-planned, secondary Bayesian analysis of the AID-ICU trial.Intensive care medicine · 2023Trial
- Incidence and risk factors for delirium in cardiac surgery intensive care unit patients: A single-center study.World journal of critical care medicine · 2026Article
- Nurses' Knowledge and Practices Regarding Delirium Management in Intensive Care Units in Cyprus: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Trends in Antipsychotic Drug Use in the United States, 2000-2016.Pharmacy (Basel, Switzerland) · 2026Article
- Delirium after cardiac arrest: incidence, risk factors, and association with neurologic outcome-insights from the Freiburg Delirium Registry.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Discovery of novel protective agents for infection-related delirium through bispectral electroencephalography.Translational psychiatry · 2024Article
- A Comparative Analysis of the Effects of Haloperidol and Dexmedetomidine on QTc Interval Prolongation during Delirium Treatment in Intensive Care Units.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2024Article
- How does haloperidol influence the long-term outcomes of delirium?Intensive care medicine · 2024Article
- Evaluating Nutritional Risk Factors for Delirium in Intensive-Care-Unit Patients: Present Insights and Prospects for Future Research.Clinics and practice · 2023Review
- Haloperidol and delirium: what is next?Intensive care medicine · 2023Article
- Clinical Features of Delirium among Patients in the Intensive Care Unit According to Motor Subtype Classification: A Retrospective Longitudinal Study.Yonsei medical journal · 2023Article
- Natural language processing diagnosed behavioural disturbance phenotypes in the intensive care unit: characteristics, prevalence, trajectory, treatment, and outcomes.Critical care (London, England) · 2023Article
- Haloperidol-induced sudden cardiac arrest in a recently detected HIV and hepatitis C patient: A unique case report.SAGE open medical case reports · 2023Article
- Olanzapine for the treatment of ICU delirium: a systematic review and meta-analysis.Therapeutic advances in psychopharmacology · 2023Article
Corrections and comments
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Authors and funding
22 authors.
Funding
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Abstract
purposeWe assessed the prevalence and variables associated with haloperidol use for delirium in ICU patients and explored any associations of haloperidol use with 90-day mortality.
methodsAll acutely admitted, adult ICU patients were screened during a 2-week inception period. We followed the patient throughout their ICU stay and assessed 90-day mortality. We assessed patients and their variables in the first 24 and 72 h in ICU and studied their association together with that of ICU characteristics with haloperidol use.
resultsWe included 1260 patients from 99 ICUs in 13 countries. Delirium occurred in 314/1260 patients [25% (95% confidence interval 23-27)] of whom 145 received haloperidol [46% (41-52)]. Other interventions for delirium were benzodiazepines in 36% (31-42), dexmedetomidine in 21% (17-26), quetiapine in 19% (14-23) and olanzapine in 9% (6-12) of the patients with delirium. In the first 24 h in the ICU, all subtypes of delirium [hyperactive, adjusted odds ratio (aOR) 29.7 (12.9-74.5); mixed 10.0 (5.0-20.2); hypoactive 3.0 (1.2-6.7)] and circulatory support 2.7 (1.7-4.3) were associated with haloperidol use. At 72 h after ICU admission, circulatory support remained associated with subsequent use of haloperidol, aOR 2.6 (1.1-6.9). Haloperidol use within 0-24 h and within 0-72 h of ICU admission was not associated with 90-day mortality [aOR 1.2 (0.5-2.5); p = 0.66] and [aOR 1.9 (1.0-3.9); p = 0.07], respectively.
conclusionsIn our study, haloperidol was the main pharmacological agent used for delirium in adult patients regardless of delirium subtype. Benzodiazepines, other anti-psychotics and dexmedetomidine were other frequently used agents. Haloperidol use was not statistically significantly associated with increased 90-day mortality.
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