ArticleNanoscale research letters2018
Evaluating the antimicrobial, apoptotic, and cancer cell gene delivery properties of protein-capped gold nanoparticles synthesized from the edible mycorrhizal fungus Tricholoma crassum.
Article in Nanoscale research letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Current challenges and future directions in the green synthesis of nanoparticles using fungi.Bioprocess and biosystems engineering · 2026Review
- A dual methane production mechanism mediated by enzymatic catalysis and the Fenton reaction in the wood-rotting fungusApplied and environmental microbiology · 2026Article
- Synergestic Protein-Green synthesized Nanoparticles Nanosystems: A Sustainable and Safe Approach for Cancer Theranostics.Nanotheranostics · 2025Review
- Fungal Methane Production Under High Hydrostatic Pressure in Deep Subseafloor Sediments.Microorganisms · 2024Article
- Exploring delivery systems for targeted nanotechnology-based gene therapy in the inner ear.Therapeutic delivery · 2024Review
- Diversity of Biogenic Nanoparticles Obtained by the Fungi-Mediated Synthesis: A Review.Biomimetics (Basel, Switzerland) · 2022Review
- Mycology-Nanotechnology Interface: Applications in Medicine and Cosmetology.International journal of nanomedicine · 2022Review
- Microwave-Assisted Chitosan-Functionalized Graphene Oxide as Controlled Intracellular Drug Delivery Nanosystem for Synergistic Antitumour Activity.Nanoscale research letters · 2021Article
- Green Silver and Gold Nanoparticles: Biological Synthesis Approaches and Potentials for Biomedical Applications.Molecules (Basel, Switzerland) · 2021Review
- Biosynthesis and Antibacterial Activity of Silver Nanoparticles Using Yeast Extract as Reducing and Capping Agents.Nanoscale research letters · 2020Article
- The Use of Nanomedicine for Targeted Therapy against Bacterial Infections.Antibiotics (Basel, Switzerland) · 2019Review
- The Apoptosis Effect on Liver Cancer Cells of Gold Nanoparticles Modified with Lithocholic Acid.Nanoscale research letters · 2018Article
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Authors and funding
7 authors.
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Abstract
Biosynthesis of gold nanoparticles of distinct geometric shapes with highly functional protein coats without additional capping steps is rarely reported. This study describes green synthesis of protein-coated gold nanoparticles for the first time from the edible, mycorrhizal fungus Tricholoma crassum (Berk.) Sacc. The nanoparticles were of the size range 5-25 nm and of different shapes. Spectroscopic analysis showed red shift of the absorption maxima with longer reaction period during production and blue shift with increase in pH. These were characterized with spectroscopy, SEM, TEM, AFM, XRD, and DLS. The particle size could be altered by changing synthesis parameters. These had potent antimicrobial activity against bacteria, fungi, and multi-drug-resistant pathogenic bacteria. These also had inhibitory effect on the growth kinetics of bacteria and germination of fungal spores. These showed apoptotic properties on eukaryotic cells when tested with comet assays. Moreover, the particles are capped with a natural 40 kDa protein which was utilized as attachment sites for genes to be delivered into sarcoma cancer cells. The present work also attempted at optimizing safe dosage of these nanoparticles using hemolysis assays, for application in therapy. Large-scale production of the nanoparticles in fermentors and other possible applications of the particles have been discussed.
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