ReviewAnimal nutrition (Zhongguo xu mu shou yi xue hui)2017
Weaning stress and gastrointestinal barrier development: Implications for lifelong gut health in pigs.
Review in Animal nutrition (Zhongguo xu mu shou yi xue hui), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 277 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
277 citing papers in PubMed, 1 synthesis or guideline pooled it, 443 citations in OpenAlex.
- Development of an indigestible dietary protein index to investigate the effects of dietary protein content in postweaned pigs.Journal of animal science · 2025Pooled it
- Age-related remodeling of the intestinal mucus barrier in pigs: implications for post-weaning diarrhea.Veterinary and animal science · 2026Article
- Antioxidant Responses to Dietary Supplementation With Non-Enriched and Selenium-Enriched Mushrooms and Selenized Yeast in Piglets.Molecular nutrition & food research · 2026Article
- Effects of dietary ergosterol supplementation on growth performance, antioxidant capacity, and intestinal health in weaned pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Alteration of Acid-Binding Capacity of Various Nursery Pig Diets and Its Influence on Properties of Digesta Along the Gastrointestinal Tract.Journal of animal physiology and animal nutrition · 2026Article
- Tissue and cellular spatiotemporal dynamics in colon aging.Nature biotechnology · 2026Article
- Article
- Sheep-derived probiotics alleviate weaning-induced oxidative stress in lambs via the gut-liver axis.NPJ biofilms and microbiomes · 2026Article
- Prevalence, spatial distribution, and risk factors associated with pneumonic lesions in weaning guinea pigs from Pasto, Colombia.Tropical animal health and production · 2026Article
- Host-Microbiota Interactions in the Regulation of Intestinal Health in Weaned Piglets: Molecular Mechanisms and Nutritional Intervention Strategies.Animals : an open access journal from MDPI · 2026Review
- Kluyveromyces marxianus CIDCA 9121 as Probiotic Supplement for Sows and Piglets: Effects on Biological and Productive Outcomes During Early Post-weaning.Probiotics and antimicrobial proteins · 2026Article
- Article
- Early-Life Swine Inflammation and Necrosis Syndrome Is Associated with Later Tail Integrity and Systemic Hematological Changes in Organically Raised Pigs.Animals : an open access journal from MDPI · 2026Article
- Research summary: influence of immune and oxidative stress biomarkers ins the jejunal mucosa on growth performance of nursery pigs.Animal frontiers : the review magazine of animal agriculture · 2026Article
- Dietary serine supplementation improves growth performance and intestinal immunity and modulates gut microbiota in chronic oxidative stress-induced weaned piglets.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Comparative evaluation of post-mortem methods for detection of diarrhoea in early-life piglets.Porcine health management · 2026Article
- Potential Role of Brown Macroalgae on Pig Health: A Review.ACS nutrition science · 2026Review
- Combined Supplementation of Live Yeast and Yeast Postbiotics Enhances Antioxidant Capacity and Intestinal Health in Weaned Piglets.Antioxidants (Basel, Switzerland) · 2026Article
- Butyrate combined with niacin enhances intestinal barrier function repair in weaned piglets infected with ETEC by promoting colonic metabolism and antimicrobial peptide expression.Journal of animal science and biotechnology · 2026Article
- Evaluation on Growth Performance, Nutrient Digestibility and Fecal Scores in Weaning Pigs Fed Wheat Bran- or Beet Pulp-Based Diets.Animals : an open access journal from MDPI · 2026Article
217 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The gastrointestinal (GI) barrier serves a critical role in survival and overall health of animals and humans. Several layers of barrier defense mechanisms are provided by the epithelial, immune and enteric nervous systems. Together they act in concert to control normal gut functions (e.g., digestion, absorption, secretion, immunity, etc.) whereas at the same time provide a barrier from the hostile conditions in the luminal environment. Breakdown of these critical GI functions is a central pathophysiological mechanism in the most serious GI disorders in pigs. This review will focus on the development and functional properties of the GI barrier in pigs and how common early life production stressors, such as weaning, can alter immediate and long-term barrier function and disease susceptibility. Specific stress-related pathophysiological mechanisms responsible for driving GI barrier dysfunction induced by weaning and the implications to animal health and performance will be discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.