ArticleAnimal nutrition (Zhongguo xu mu shou yi xue hui)2016
Leucine increases mucin 2 and occludin production in LS174T cells partially via PI3K-Akt-mTOR pathway.
Article in Animal nutrition (Zhongguo xu mu shou yi xue hui), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 18 citations in OpenAlex.
- The functional antagonist of sphingosine-1-phosphate, FTY720, impairs gut barrier function.Frontiers in pharmacology · 2024Article
- Occludin: a gatekeeper of brain Infection by HIV-1.Fluids and barriers of the CNS · 2023Review
- Dietary Leucine Improves Fish Intestinal Barrier Function by Increasing Humoral Immunity, Antioxidant Capacity, and Tight Junction.International journal of molecular sciences · 2023Article
- Glutamine, but not Branched-Chain Amino Acids, Restores Intestinal Barrier Function during Activity-Based Anorexia.Nutrients · 2019Article
- Leucine modulates the IPEC-J2 cell proteome associated with cell proliferation, metabolism and phagocytosis.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2018Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
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Abstract
Mucin 2 and occludin play a crucial role in preserving the intestinal mucosal integrity. However, the role for leucine mediating intestinal mucin 2 and occludin expression has little been investigated. The current study was conducted to test the hypothesis that leucine treatment could increase mucin 2 and occludin levels in LS174T cells. The LS174T cells were incubated in the Dulbecco's Modified Eagle Medium (DMEM) supplementing 0, 0.5 and 5 mmol/L L-leucine for the various durations. Two hours after the leucine treatment, the inhibitor of mammalian target of rapamycin (mTOR) and protein kinase B (Akt) phosphorylation in LS174T cells were significantly increased (
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