Evidence map›Paper›PMID 29766765›Full record

ArticleJournal of neurophysiology2018

Control of transitions between locomotor-like and paw shake-like rhythms in a model of a multistable central pattern generator.

Jessica Parker, Brian Bondy, Boris I Prilutsky, Gennady Cymbalyuk

Open access · bronzeAbstract read
In one paragraph

Article in Journal of neurophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
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  6. Comodulation of h- and NaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  7. Review
  8. Contributions of h- and NaFrontiers in cellular neuroscience · 2021
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jessica ParkerNeuroscience Institute, Georgia State University , Atlanta, Georgia.
Brian BondyNeuroscience Institute, Georgia State University , Atlanta, Georgia.
Boris I PrilutskySchool of Biological Sciences, Georgia Institute of Technology , Atlanta, Georgia.
Gennady CymbalyukNeuroscience Institute, Georgia State University , Atlanta, Georgia.ORCID 0000-0002-1889-5397
Georgia State University · USGeorgia Institute of Technology · US

Funding

SPINAL CIRCUITS &THE MUSCULOSKELETAL SYSTEMP01HD032571 · NICHD · EMORY UNIVERSITY · PI GOOLSBY, WILLIAM · 1995 to 2016
$16.2M
Neural mechanisms of locomotion evoked by epidural stimulation of the spinal cordR01NS100928 · NINDS · GEORGIA INSTITUTE OF TECHNOLOGY · PI PRILUTSKY, BORIS I · 2017 to 2021
$2.7M
Training in Learning and MemoryT32MH106454 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI PRESTON, ALISON R · 2015 to 2025
$2.1M
CRCNS: Role of sensory feedback in locomotor recovery after spinal cord injuryR01EB012855 · NIBIB · DREXEL UNIVERSITY · PI LEMAY, MICHEL A · 2010 to 2013
$1.3M
NIBIB NIH HHS R01 EB012855NICHD NIH HHS P01 HD032571NIMH NIH HHS T32 MH106454NINDS NIH HHS R01 NS100928
6 · The paper itself

Abstract

The ability of the same neuronal circuit to control different motor functions is an actively debated concept. Previously, we showed in a model that a single multistable central pattern generator (CPG) could produce two different rhythmic motor patterns, slow and fast, corresponding to cat locomotion and paw shaking. A locomotor-like rhythm (~1 Hz) and a paw shake-like rhythm (~10 Hz) did coexist in our model, and, by applying a single pulse of current, we could switch the CPG from one regime to another (Bondy B, Klishko AN, Edwards DH, Prilutsky BI, Cymbalyuk G. In: Neuromechanical Modeling of Posture and Locomotion, 2016). Here we investigated the roles of slow intrinsic ionic currents in this multistability. The CPG is modeled as a half-center oscillator circuit comprising two reciprocally inhibitory neurons. Each neuron is equipped with two slow inward currents, a Na

Indexed as

Models, NeurologicalAnimalsCatsCentral Pattern GeneratorsComputer SimulationHindlimbInterneuronsLocomotionMembrane PotentialsMotor ActivityNeurotransmitter AgentsNeurotransmitter Agentscentral pattern generatorhalf-center oscillatorlocomotionmultistabilitypaw shaking

Identifiers

PMID29766765
PMCPMC6171058
OpenAlexW2803427291

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.