ArticleJournal of cachexia, sarcopenia and muscle2018
The deterioration of muscle mass and radiodensity is prognostic of poor survival in stage I-III colorectal cancer: a population-based cohort study (C-SCANS).
Article in Journal of cachexia, sarcopenia and muscle, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
74 citing papers in PubMed, 4 syntheses or guidelines pooled it, 124 citations in OpenAlex.
- The Prognostic Value of Sarcopenia in Clinical Outcomes in Cervical Cancer: A Systematic Review and Meta-Analysis.Journal of cachexia, sarcopenia and muscle · 2025Pooled it
- Body Composition and Prostate Cancer Risk: A Systematic Review of Observational Studies.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- Function Over Mass: A Meta-Analysis on the Importance of Skeletal Muscle Quality in COVID-19 Patients.Frontiers in nutrition · 2022Pooled it
- Sarcopenia and ovarian cancer survival: a systematic review and meta-analysis.Journal of cachexia, sarcopenia and muscle · 2019Pooled it
- A novel prognostic model integrating the skeletal muscle index and systemic immune-inflammation index improves outcome prediction in unresectable esophageal squamous cell carcinoma.The British journal of radiology · 2026Article
- Comment on "Sarcopenia as a Predictor of Mortality Following Vertebral Compression Fractures Treated with Vertebroplasty".Global spine journal · 2026Article
- Prognostic Significance of Sarcopenia in Colorectal Cancer: A Review of Clinical Evidence.Cancer management and research · 2026Review
- Artificial Intelligence-Derived 3D Body Composition Analysis of the Entire Lumbar Region From CT Scans Reveals Variation Across Disease Stages at Colorectal Cancer Diagnosis.Radiology research and practice · 2026Article
- Article
- Psychometric Validation of the Arabic FRAIL Scale for Frailty Assessment Among Older Adults with Colorectal Cancer.Healthcare (Basel, Switzerland) · 2025Article
- Artificial Intelligence-Derived Intramuscular Adipose Tissue Assessment Predicts Perineal Wound Complications Following Abdominoperineal Resection.World journal of surgery · 2025Article
- Sarcopenia and Myosteatosis as a Predictor of Post-Operative Outcomes in Patients Undergoing Laparotomy for Abdominal Emergencies.Journal of clinical medicine · 2025Article
- Cancer-Associated Cachexia: Bridging Clinical Findings with Mechanistic Insights in Human Studies.Cancer discovery · 2025Review
- A rapid review of nutrition and exercise approaches to managing unintentional weight loss, muscle loss, and malnutrition in cancer.The oncologist · 2025Review
- Article
- Predictive value of preoperative subcutaneous and intramuscular adipose tissue for the occurrence of postoperative liver metastasis in gastric cancer patients undergoing radical gastrectomy.Journal of gastrointestinal oncology · 2025Article
- Not all colon cancer patients with preoperative hyperinflammatory status are at high risk of muscle loss and poor prognosis.International journal of colorectal disease · 2025Article
- Review
- Myosteatosis as an independent predictor for all-cause and cardiac mortality in initial-dialysis patients: a multicenter, retrospective cohort study.Frontiers in physiology · 2025Article
- Impact of body composition and muscle health phenotypes on survival outcomes in colorectal cancer: a multicenter cohort.Scientific reports · 2024Article
14 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundMuscle abnormalities such as low muscle mass and low muscle radiodensity are well known risk factors for unfavourable cancer prognosis. However, little is known in regard to the degree and impact of longitudinal changes in muscle mass and radiodensity within the context of cancer. Here, we explore the relationship between muscle wasting and mortality in a large population-based study of patients with non-metastatic colorectal cancer (CRC).
methodsA total of 1924 patients with stage I-III CRC who underwent surgical resection in the Kaiser Permanente Northern California Health System were included. Muscle mass and radiodensity were quantified using computed tomography images obtained at diagnosis and after approximately 14 months. Cox proportional-hazards models were used to estimate hazard ratios for all-cause mortality.
resultsThe hazard ratio for all-cause mortality among patients with the largest deterioration in muscle mass (≥2 SD; ≥11.4% loss from baseline), as compared with those who remained stable (±1 SD; 0.0 ± 5.7%) was 2.15 [95% confidence interval (CI): 1.59-2.92; P < 0.001]. The hazard ratio for all-cause mortality among patients who experienced the largest deterioration in muscle radiodensity (≥2 SD; ≥20.2% loss from baseline), as compared with those who remained stable (±1 SD; 0.0 ± 10.1%) was 1.61 (95% CI: 1.20-2.15; P = 0.002).
conclusionsIn patients with stage I-III CRC, muscle wasting is a risk factor for mortality, independent of change in body mass and other body composition parameters.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.