ReviewCNS neuroscience & therapeutics2018
Organic psychosis: The pathobiology and treatment of delusions.
Review in CNS neuroscience & therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Neurosyphilis-Induced Psychosis in Europe: A Systematic Review of Case Reports.Pathogens (Basel, Switzerland) · 2024Pooled it
- Glioblastoma Masquerading as a Presumed Ischemic Stroke: A Case of Delusional Jealousy and Fluctuating Psychosis.Cureus · 2026Article
- Hypopituitarism Accompanied with Delusion: The Effects of Growth Hormone Replacement Therapy.Internal medicine (Tokyo, Japan) · 2026Article
- How common is secondary psychosis? Estimates from a systematic review and meta-analysis.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- The predictive role of family history of antipsychotic drug use in poor outcomes following aneurysmal subarachnoid hemorrhage (aSAH).Brain & spine · 2025Article
- Diagnosing Late-Onset Psychosis in a Medically Complex Patient: A Diagnostic Challenge.Cureus · 2024Article
- Temperament & Character account for brain functional connectivity at rest: A diathesis-stress model of functional dysregulation in psychosis.Molecular psychiatry · 2023Review
- Ectopic parathyroid adenoma causing hyperparathyroidism-induced psychosis: A case report.SAGE open medical case reports · 2023Article
- Treatment resistant psychosis in children and adolescents and clozapine: Nuances.Frontiers in psychiatry · 2023Review
- Improved psychotic symptoms following resection of amygdalar low-grade glioma: illustrative case.Journal of neurosurgery. Case lessons · 2022Article
- Spectrum of neuropsychiatric symptoms in chronic post-stroke aphasia.World journal of psychiatry · 2022Article
- Drug-induced Delusional Infestation.Acta dermato-venereologica · 2022Review
- Integrated case-based clinical approach in understanding pathways, complexities, pitfalls and challenges in neurodegenerative disorders.American journal of neurodegenerative disease · 2022Article
- Dilemma of Treating Psychosis Secondary to Stroke.Cureus · 2021Article
- Article
- Two Case Studies of Delusions Leading to Suicide, a Selective Review.The Psychiatric quarterly · 2020Review
- Neuropsychiatric issues after stroke: Clinical significance and therapeutic implications.World journal of psychiatry · 2020Review
- Psychosis in Parkinson's disease and parkinsonism in antipsychotic-naive schizophrenia spectrum psychosis: clinical, nosological and pathobiological challenges.Acta pharmacologica Sinica · 2020Review
- Nosology and Phenomenology of Psychosis in Movement Disorders.Movement disorders clinical practice · 2020Review
- Chronic Post-stroke Psychosis with Left Cortical and Bilateral Inferior Cerebellar Involvement.Cureus · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Organic or secondary psychosis can be seen in diverse conditions such as toxic/metabolic disorders, neurodegenerative disease, and stroke. Poststroke psychosis is a rare phenomenon, but its study has significantly contributed to the understanding of delusion formation. The evidence from case studies of patients with focal strokes shows that delusions develop following unilateral damage of the right hemisphere. The majority of patients with right hemisphere stroke do not develop delusions however, and advanced neuroimaging analysis has elucidated why this symptom develops in only a small proportion. Lesions of the right lateral prefrontal cortex or lesions with connectivity to this area correlate with delusional beliefs in this subgroup. Studies of patients with primary psychosis, for example schizophrenia, or under the influence of the psychotogenic drug ketamine, also show abnormal function of this area in relation to the severity of their abnormal beliefs. The conclusion of these studies is that the right lateral prefrontal cortex is 1 hub in a neural network which includes the basal ganglia and limbic system and receives inputs from midbrain dopamine neurones. In patients with schizophrenia, or at risk of psychosis, dopamine is dysregulated and evidence suggests that faulty dopamine signaling is the precursor of delusion formation. It is therefore likely that the mechanism of delusion formation is the same in both primary and secondary psychosis. This is consistent with the mainstay of treatment of both conditions being antipsychotic medication. However, antipsychotic medication in people with cerebrovascular disease should be avoided if at all possible. This is because epidemiological studies have found that antipsychotic use is associated with an increased risk of stroke and will thus compound the possibility of a further cerebrovascular accident.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.