Evidence map›Paper›PMID 29766601›Full record

ArticleExperimental physiology2018

Functional high-intensity exercise training ameliorates insulin resistance and cardiometabolic risk factors in type 2 diabetes.

Ciarán E Fealy, Stephan Nieuwoudt, Julie A Foucher, Amanda R Scelsi, Steven K Malin, Mangesh Pagadala, Lauren A Cruz, Miranda Li, Michael Rocco, Bartolome Burguera and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Experimental physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 82 citations in OpenAlex.

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  7. Tailoring Exercise Prescription for Effective Diabetes Glucose Management.The Journal of clinical endocrinology and metabolism · 2025
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  19. Exercise therapy for sarcopenia and diabetes.World journal of diabetes · 2023
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Ciarán E FealyDepartment of Pathobiology, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, USA.
Stephan NieuwoudtDepartment of Pathobiology, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, USA.
Julie A FoucherDepartment of Pathobiology, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, USA.
Amanda R ScelsiDepartment of Pathobiology, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, USA.
Steven K MalinDepartment of Pathobiology, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, USA.
Mangesh PagadalaDepartment of Pathobiology, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, USA.
Lauren A CruzDepartment of Pathobiology, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, USA.
Miranda LiDepartment of Pathobiology, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, USA.
Michael RoccoDepartment of Cardiology, Cleveland Clinic, Cleveland, OH, USA.
Bartolome BurgueraEndocrinology and Metabolism Institute, Cleveland Clinic, Cleveland, OH, USA.
John P KirwanDepartment of Pathobiology, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, USA.ORCID 0000-0001-7321-9917
Cleveland Clinic Lerner College of Medicine · USCleveland Clinic · USKent State University · US

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024989 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$53.7M
Clinical and Translational Science Collaborative of ClevelandUL1TR002548 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2018 to 2022
$35.5M
CWRU- Cardiovascular Research Training ProgramT32HL134622 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI JAIN, MUKESH KUMAR, PROWELLER, AARON · 2017 to 2021
$1.9M
NCATS NIH HHS UL1 TR002548NCRR NIH HHS UL1 RR024989NHLBI NIH HHS T32 HL134622
6 · The paper itself

Abstract

NEW

findingsWhat is the central question of this study? Does short-duration, high-intensity exercise training that combines functional aerobic and resistance exercises into training sessions lasting 8-20 min benefit individuals with type 2 diabetes? What is the main finding and its importance? Functional high-intensity training improves insulin sensitivity and reduces cardiometabolic risk in individuals with type 2 diabetes. This type of exercise training may be an effective exercise mode for managing type 2 diabetes. The increase in insulin sensitivity addresses a key defect in type 2 diabetes. ABSTRACT: Functional high-intensity training (F-HIT) is a novel fitness paradigm that integrates simultaneous aerobic and resistance training in sets of constantly varied movements, based on real-world situational exercises, performed at high-intensity in workouts that range from ∼8 to 20 min per session. We hypothesized that F-HIT would be an effective exercise mode for reducing insulin resistance in type 2 diabetes (T2D). We recruited 13 overweight/obese adults (5 males, 8 females; 53 ± 7 years; BMI 34.5 ± 3.6 kg m

Indexed as

High-Intensity Interval TrainingBody Mass IndexCardiovascular DiseasesDiabetes Mellitus, Type 2FemaleGlucose Tolerance TestHumansInsulin ResistanceMaleMetabolic SyndromeMiddle AgedObesityOverweightRisk FactorsCrossFit™diabetesinsulin resistanceinsulin sensitivityobesity

Identifiers

PMID29766601
PMCPMC6026040
OpenAlexW2804415505

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.