ArticleCEN case reports2018
Thrombotic microangiopathy on kidney biopsy in a patient with TAFRO syndrome.
Article in CEN case reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Successful treatment of idiopathic multicentric Castleman disease with TAFRO and kidney involvement: case report and literature review.Renal failure · 2026Review
- Morphological characteristics of the renal lesion in TAFRO syndrome and POEMS syndrome: a retrospective and multicenter study.Clinical and experimental nephrology · 2026Article
- Retrospective cohort evaluation of renal involvement in non-HIV castleman disease patients from a single academic center in Beijing, China.Annals of hematology · 2026Article
- A case of TAFRO syndrome after vaccination, successfully treated with cyclosporine.BMC nephrology · 2024Article
- Unraveling TAFRO Syndrome: An In-Depth Look at the Pathophysiology, Management, and Future Perspectives.Biomedicines · 2024Review
- Severe TAFRO Syndrome Mimicking Hepatorenal Syndrome Successfully Treated with a Multidisciplinary Approach: A Case Report and Literature Review.Internal medicine (Tokyo, Japan) · 2023Review
- Case Report: A case of TAFRO syndrome with severe and prolonged thrombocytopenia: diagnostic pitfalls.Frontiers in immunology · 2023Article
- Five biopsies, one diagnosis: challenges in idiopathic multicentric Castleman disease.BMJ case reports · 2020Article
- Kidney biopsy findings in two patients with TAFRO syndrome: case presentations and review of the literature.BMC nephrology · 2020Review
- Computed tomography findings of early-stage TAFRO syndrome and associated adrenal abnormalities.European radiology · 2020Article
- The Clinical and Histopathological Feature of Renal Manifestation of TAFRO Syndrome.Kidney international reports · 2020Article
- Unexplained cause of thrombocytopenia, fever, anasarca and hypothyroidism: TAFRO syndrome with thrombotic microangiopathy renal histology.BMJ case reports · 2020Article
- Pathological findings of progressive renal involvement in a patient with TAFRO syndrome.CEN case reports · 2019Article
- TAFRO syndrome as a cause of glomerular microangiopathy: a case report and literature review.BMC nephrology · 2019Review
- An autopsy case of TAFRO syndrome with membranoproliferative glomerulonephritis-like lesions.CEN case reports · 2019Article
- Renal Pathologic Findings in TAFRO Syndrome: Is There a Continuum Between Thrombotic Microangiopathy and Membranoproliferative Glomerulonephritis? A Case Report and Literature Review.Frontiers in immunology · 2019Review
- TAFRO Syndrome With Kidney Involvement: A Case Series of Patients With Kidney Biopsies.Kidney medicineArticle
- Updates on the diagnosis and management of multicentric Castleman disease.Tzu chi medical journalReview
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
TAFRO syndrome represents a characteristic constellation of symptoms comprising Thrombocytopenia, Anasarca, myeloFibrosis, Renal dysfunction, and Organomegaly, and is considered to be a clinicopathologic variant of idiopathic multicentric Castleman disease. A 51-year-old woman was admitted to the hospital complaining of abdominal distension. Findings on physical examination were indicative of anasarca. Computed tomography revealed mild splenomegaly, pericardial effusion, pleural effusion, ascites, and paraaortic lymphadenopathy. Blood tests showed thrombocytopenia, and urinalysis demonstrated hematuria, proteinuria, and worsening renal function. Kidney biopsy was performed and revealed thrombotic microangiopathy-like lesions with global sclerosis of 1 of the 16 glomeruli on light microscopy. The remaining glomeruli had a distinct lobular pattern, with mesangiolysis, double contours of the glomerular basement membranes, and marked endothelial swelling. Immunofluorescence studies for IgG, IgM, IgA, C1q, C3, C4, κ-light chains, and λ-light chains were indeterminate. Electron microscopy showed marked endothelial swelling. We made a diagnosis of TAFRO syndrome and started steroid treatment, following which her symptoms gradually improved. There are few reports describing renal pathology in a patient with TAFRO syndrome.
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