ArticleCerebellum (London, England)2018
Cerebellar-Stimulation Evoked Prefrontal Electrical Synchrony Is Modulated by GABA.
Article in Cerebellum (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cerebral Cortical Activity Following Non-invasive Cerebellar Stimulation-a Systematic Review of Combined TMS and EEG Studies.Cerebellum (London, England) · 2020Pooled it
- Exploring Neurobiological Effects of Intermittent Theta-Burst Stimulation on the Left Cerebellum for Post-stroke Unilateral Neglect: A Preliminary Transcranial Magnetic Stimulation-Electroencephalography Investigation.Cerebellum (London, England) · 2025Trial
- Neural effects of TMS trains on the human prefrontal cortex.Scientific reports · 2023Trial
- Trial
- Temporal Pattern-Dependent Cerebellar Involvement in Conflict Processing: An Online Transcranial Magnetic Stimulation Study.Cerebellum (London, England) · 2026Article
- Cortical dysfunction and impulsivity in non-suicidal self-injury: a multimodal study using TMS-EEG and fNIRS.Annals of medicine · 2025Article
- Advances in Cerebellar TMS Therapy: An Updated Systematic Review on Multi-Session Interventions.Biomedicines · 2025Review
- Cerebellar Neurostimulation for Boosting Social and Affective Functions: Implications for the Rehabilitation of Hereditary Ataxia Patients.Cerebellum (London, England) · 2024Review
- The Past, Current and Future Research in Cerebellar TMS Evoked Responses-A Narrative Review.Brain sciences · 2024Review
- Neural effects of TMS trains on the human prefrontal cortex.bioRxiv : the preprint server for biology · 2023Article
- Utilising TMS-EEG to Assess the Response to Cerebellar-Brain Inhibition.Cerebellum (London, England) · 2023Article
- Assessing CBI with TMS-EEG.Cerebellum (London, England) · 2023Article
- New Horizons on Non-invasive Brain Stimulation of the Social and Affective Cerebellum.Cerebellum (London, England) · 2022Review
- Non-invasive Brain Stimulation of the Cerebellum in Emotion.Advances in experimental medicine and biology · 2022Article
- The correlations between kinematic profiles and cerebral hemodynamics suggest changes of motor coordination in single and bilateral finger movement.Frontiers in human neuroscience · 2022Article
- Cerebellar Coordination of Neuronal Communication in Cerebral Cortex.Frontiers in systems neuroscience · 2021Article
- Risk Variants in Three Alzheimer's Disease Genes Show Association with EEG Endophenotypes.Journal of Alzheimer's disease : JAD · 2021Article
- The role of transcranial magnetic stimulation in understanding attention-related networks in single subjects.Current research in neurobiology · 2021Review
- Genome-Wide Scan for Five Brain Oscillatory Phenotypes Identifies a New QTL Associated with Theta EEG Band.Brain sciences · 2020Article
- Concurrent TMS-EEG and EEG reveal neuroplastic and oscillatory changes associated with self-compassion and negative emotions.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Cerebellar-prefrontal connectivity has been recognized as important for behaviors ranging from motor coordination to cognition. Many of these behaviors are known to involve excitatory or inhibitory modulations from the prefrontal cortex. We used cerebellar transcranial magnetic stimulation (TMS) with simultaneous electroencephalography (EEG) to probe cerebellar-evoked electrical activity in prefrontal cortical areas and used magnetic resonance spectroscopy (MRS) measures of prefrontal GABA and glutamate levels to determine if they are correlated with those potentials. Cerebellar-evoked bilateral prefrontal synchrony in the theta to gamma frequency range showed patterns that reflect strong GABAergic inhibitory function (r = - 0.66, p = 0.002). Stimulation of prefrontal areas evoked bilateral prefrontal synchrony in the theta to low beta frequency range that reflected, conversely, glutamatergic excitatory function (r = 0.66, p = 0.002) and GABAergic inhibitory function (r = - 0.65, p = 0.002). Cerebellar-evoked prefrontal synchronization had opposite associations with cognition and motor coordination: it was positively associated with working memory performance (r = 0.57, p = 0.008) but negatively associated with coordinated motor function as measured by rapid finger tapping (r = - 0.59, p = 0.006). The results suggest a relationship between regional GABA levels and interregional effects on synchrony. Stronger cerebellar-evoked prefrontal synchrony was associated with better working memory but surprisingly worse motor coordination, which suggests competing effects for motor activity and cognition. The data supports the use of a TMS-EEG-MRS approach to study the neurochemical basis of large-scale oscillations modulated by the cerebellar-prefrontal connectivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.