Evidence map›Paper›PMID 29766398›Full record

ArticleClinical journal of gastroenterology2018

Hepatosplenic T cell lymphoma: a unifying entity in a patient with hemolytic anemia, massive splenomegaly, and liver dysfunction.

Marianna Mavilia, Agnes McAuliffe, Safina Hafeez, Haleh Vaziri

Abstract readCase Reports
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In one paragraph

Article in Clinical journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Marianna MaviliaDepartment of Medicine, University of Connecticut, 263 Farmington Ave, Farmington, CT, 06030, USA. mmavilia@uchc.edu.
Agnes McAuliffeDepartment of Medicine, University of Connecticut, 263 Farmington Ave, Farmington, CT, 06030, USA.
Safina HafeezDepartment of Pathology, Hartford Hospital, Hartford, CT, USA.
Haleh VaziriDepartment of Gastroenterology and Hepatology, University of Connecticut, Farmington, CT, USA.
University of Connecticut · USHartford Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatosplenic T cell lymphoma (HSTCL) is a rare subtype of peripheral non-Hodgkin lymphoma, of which 20% of cases are associated with chronic immunosuppression. It often occurs in patients with inflammatory bowel disease treated with immunomodulating medications such a thiopurines or TNF-alpha inhibitors. Cytopenias are commonly seen but autoimmune hemolytic anemia (AIHA) is rare. Here we present a young male with longstanding ulcerative colitis on chronic azathioprine, exhibiting several rare features of HSTCL. He initially presented with refractory AIHA, thrombocytopenia, and massive splenomegaly, requiring splenectomy. Histologic examination of his spleen confirmed diagnosis of HSTCL. Approximately 3 months after diagnosis, he was found to have leukemic transformation, representing a secondary malignancy.

Indexed as

AdultAnemia, HemolyticAzathioprineBiopsyChronic DiseaseColitis, UlcerativeFatal OutcomeHumansImmunocompromised HostImmunosuppressive AgentsLiver DiseasesLiver NeoplasmsLymphoma, T-CellMagnetic Resonance ImagingMalePositron Emission Tomography Computed TomographyAzathioprineImmunosuppressive AgentsAutoimmune hemolytic anemiaInflammatory bowel diseaseLymphomaThiopurinesTNF alpha inhibitor

Identifiers

PMID29766398
OpenAlexW2803548533

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.