ReviewClinical reviews in allergy & immunology2019
Systemic Contact Dermatitis.
Review in Clinical reviews in allergy & immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 86 citations in OpenAlex.
- Finger Allergic Contact Dermatitis by Proxy Induced by Feline Thiamazole Cream.Contact dermatitis · 2026Article
- A Case of Toxic Epidermal Necrolysis-Like Dermatosis Associated With Contact Exposure to a Flurbiprofen Plaster.Cureus · 2026Article
- Systemic allergic contact dermatitis to nickel presenting predominantly as severe hand dermatitis, successfully controlled with upadacitinib: A case report.SAGE open medical case reports · 2026Article
- Article
- Updating the classification and routine diagnosis of NSAID hypersensitivity reactions: A WAO Statement.The World Allergy Organization journal · 2025Review
- Skin Prick Test and Patch Test: Environmental and Chemical Allergen Reactivity Pattern Among Yemeni Patients in Sana'a City, Yemen.Journal of asthma and allergy · 2025Article
- Carbamazepine-induced Stevens-Johnson Syndrome: A Case Report with Review of the Literature.Current drug safety · 2025Review
- An Evidence-Based Consensus for the Use of Neurostimulation for the Treatment of Non-Surgical Low Back Pain: The NEURON Group.Journal of pain research · 2025Review
- Case Report: Systemic contact dermatitis caused by benzalkonium chloride in a family (a child and parents).Frontiers in pediatrics · 2025Article
- Acidic oral environment's potential contribution to palladium-induced systemic contact dermatitis: Case report.The journal of allergy and clinical immunology. Global · 2024Article
- New Insights Concerning Phytophotodermatitis Induced by Phototoxic Plants.Life (Basel, Switzerland) · 2024Review
- Allergic Sensitization and Psychosomatic Involvement in Outdoor and Indoor Workers: A Preliminary and Explorative Survey of Motorway Toll Collectors and Office Employees.Healthcare (Basel, Switzerland) · 2024Article
- Symmetrical cutaneous rash in two women.Clinical case reports · 2024Article
- Adverse Food Reactions in Inflammatory Bowel Disease: State of the Art and Future Perspectives.Nutrients · 2024Review
- Nitric Oxide Signal Transduction and Its Role in Skin Sensitization.Biomolecules & therapeutics · 2023Review
- Allergenicity and Bioavailability of Nickel Nanoparticles Compared to Nickel Microparticles in Mice.Materials (Basel, Switzerland) · 2023Article
- A comprehensive summary of disease variants implicated in metal allergy.Journal of toxicology and environmental health. Part B, Critical reviews · 2022Review
- Recognizing Drug Hypersensitivity in Pigmented Skin.Immunology and allergy clinics of North America · 2022Review
- [Diagnostic keys for disseminated eczema: experience of a Dermatitis Contact unit (2003-2019)].Anales del sistema sanitario de Navarra · 2022Article
- Single-cell immunopathology of systemic contact allergy associated with corticosteroids.Journal of dermatological science · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Systemic contact dermatitis (SCD) traditionally refers to a skin condition where an individual who is cutaneously sensitized to an allergen will subsequently react to that same allergen or a cross reacting allergen via a different route. It occurs to allergens including metals, medications, and foods. The exact pathophysiology underlying this disease remains unknown, although it appears to be mediated by type 4 hypersensitivity reactions and possibly type 3 hypersensitivity reactions. The p-I concept (pharmacologic interaction with immunoreceptors) hypothesized that drugs are able to bind directly to a T cell receptor without first being presented by MHC (major histocompatibility complex) molecules and without prior metabolism, which would help explain why SCD can be seen on first exposure to medications. Nomenclature remains a challenge as SCD can be subcategorized using terms such as ACDS (allergic contact dermatitis syndrome) and its four clinical stages, Baboon syndrome, and SDRIFE (symmetrical drug-related intertriginous and flexural exanthema), which share many overlapping features. Food allergens may be responsible for uncontrolled or persistent symptoms in patients with contact dermatitis who do not respond to topical avoidance. With medications, symptoms may be induced by topical application versus systemic administration. Patch testing (PT) may be beneficial in diagnosing SCD caused by metals and many topical medications including corticosteroids, antimicrobials (ampicillin, bacitracin, erythromycin, neomycin, nystatin), NSAIDs (diclofenac, ibuprofen), anesthetics, and antihistamines (chlorphenamine, piperazine). Current treatment options include topical steroids and oral antihistamines for symptom relief and dietary avoidance to causative foods or metals.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.