ArticleClinical research in cardiology : official journal of the German Cardiac Society2018
Sodium levels during hospitalization with acute myocardial infarction are markers of in-hospital mortality: Soroka acute myocardial infarction II (SAMI-II) project.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 17 citations in OpenAlex.
- Serum sodium and eplerenone use in patients with a myocardial infarction and left ventricular dysfunction or heart failure: insights from the EPHESUS trial.Clinical research in cardiology : official journal of the German Cardiac Society · 2022Trial
- Article
- Dysnatremia is associated with increased risk of all-cause mortality within 365 days post-discharge in patients with atrial fibrillation without heart failure: A prospective cohort study.Frontiers in cardiovascular medicine · 2022Article
- Potassium variability during hospitalization and outcomes after discharge in patients with acute myocardial infarction.Journal of geriatric cardiology : JGC · 2021Article
- High-Normal Serum Magnesium and Hypermagnesemia Are Associated With Increased 30-Day In-Hospital Mortality: A Retrospective Cohort Study.Frontiers in cardiovascular medicine · 2021Article
- Relationship between Admission Electrolyte Level and Short-term Prognosis of Patients with Acute ST-segment Elevation Myocardial Infarction after Percutaneous Coronary Intervention.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- A Nomogram for Predicting Hospital Mortality in Intensive Care Unit Patients with Acute Myocardial Infarction.International journal of general medicine · 2021Article
- Effect of baroreflex activation therapy on renal sodium excretion in patients with resistant hypertension.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Observational
- Polyhedral erythrocytes in intracoronary thrombus and their association with reperfusion in myocardial infarction.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Article
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3 authors at 2 institutions in 1 country.
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Abstract
objectiveAbnormalities in sodium homeostasis are common in hospitalized patients. Hyponatremia upon admission is a poor prognostic marker in acute myocardial infarction (AMI) patients. However, little is known about the association between changes in sodium levels and in-hospital mortality. We delineated changes in sodium levels and studied the association of such changes with in-hospital mortality of AMI patients.
methodsRetrospective analysis of AMI patients hospitalized for > 6 days. Sodium levels throughout the 6-day post-admission were divided into five equally sized groups (quintiles = Q) and thereafter categorized as follows: Q1 (< 135 mEq/L), Q2-Q4 (135-140 mEq/L, reference group), and Q5 (≥141 mEq/L). PRIMARY OUTCOME: in-hospital mortality.
resultsA total of 8306 patients (10,416 admissions) were included (mean age 67.8 ± 14.0 years, 33.4% women, 45.5% STEMI). In-hospital mortality was 6.6%. Q1 and Q5 upon admission were both related to higher risk for in-hospital mortality, compared with the reference group (OR 1.47 and OR 1.33, respectively, p < 0.001 each). Q1 was more frequent in non-survivors throughout the entire study period, while the prevalence of Q5 levels was similar in survivors and non-survivors upon admission carrying increasing mortality risk thereafter: for Q1 consistent OR 1.50, while for Q5 it, increased from OR 1.32 upon admission to OR 1.90 on the sixth day, p < 0.001.
conclusionsLow and high sodium levels are associated with increased risk for in-hospital mortality in patients with AMI. The risk is unchanged for hyponatremia, while it consistently increases for increased sodium levels.
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