Evidence map›Paper›PMID 29766282›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2018

Parameters of pulse wave velocity: determinants and reference values assessed in the population-based study LIFE-Adult.

Daniel Baier, Andrej Teren, Kerstin Wirkner, Markus Loeffler, Markus Scholz

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Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  8. Differential effects of inhibition of interleukin 1 and 6 on myocardial, coronary and vascular function.Clinical research in cardiology : official journal of the German Cardiac Society · 2019
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  18. Usefulness of Arterial Stiffness as an Integrated Marker of Cardiovascular Risk.Journal of clinical hypertension (Greenwich, Conn.) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Daniel BaierInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16-18, 04107, Leipzig, Germany.
Andrej TerenLIFE Research Center for Civilization Diseases, Leipzig, Germany.
Kerstin WirknerLIFE Research Center for Civilization Diseases, Leipzig, Germany.
Markus LoefflerInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16-18, 04107, Leipzig, Germany.
Markus ScholzInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16-18, 04107, Leipzig, Germany. markus.scholz@imise.uni-leipzig.de.ORCID http://orcid.org/0000-0002-4059-1779

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AIMS AND

backgroundParameters of arterial stiffness such as pulse wave velocity (PWV) were recently proposed as independent risk factors of cardiovascular events. We analyse three PWV parameters in the large population-based study LIFE-Adult to identify risk factors, normal and reference values. METHODS AND

resultsBrachial-ankle (ba), brachial-femoral (bf) and carotid-femoral (cf) PWV assessment was performed using Vicorder device. 8509 participants aged 19-80 were analysed. PWV parameters were moderately correlated (r(ba/bf) = 0.6, r(ba/cf) = 0.46, r(bf/cf) = 0.59). Age and blood pressure are the dominant determinants of PWV parameters explaining > 18% of variability. Sex was only relevant for bfPWV and cfPWV. All further analysed cardiovascular and other risk factors are of minor importance. We provide age-dependent percentiles for the population (reference values) and for the subgroup of normotonic individuals. All percentiles show a strong increase with age. The difference between normotonic and all individuals is small for younger age groups but increases up to 1 m/s for elderly subjects.

conclusionOur study confirms and further underpins the strong impact of age and blood pressure on arterial stiffness and the relatively weak contribution of other factors, supporting an independent role of arterial stiffness in cardiovascular disease development. Age-dependent reference and normal values were provided on the basis of the so far largest study sample facilitating the implementation of PWV assessment in clinical practice. Due to better compliance, handling and stronger association with age and blood pressure, baPWV could serve as an alternative to cfPWV. Follow-up data are required to estimate the clinical significance of specified PWV cut-offs.

Indexed as

Population SurveillanceAdultAgedAged, 80 and overAnkle Brachial IndexBlood PressureBrachial ArteryCardiovascular DiseasesCarotid ArteriesFemaleFemoral ArteryFollow-Up StudiesGermanyHumansMaleMiddle AgedArterial stiffnessBlood pressureBrachial to ankleBrachial to femoralCardiovascular risk stratificationCarotid to femoral

Identifiers

PMID29766282
PMCPMC6208658

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.