Evidence map›Paper›PMID 29766276›Full record

ArticleJournal of gastroenterology2018

Anti-ganglionic AChR antibodies in Japanese patients with motility disorders.

Akihiro Mukaino, Hitomi Minami, Hajime Isomoto, Hitomi Hamamoto, Eikichi Ihara, Yasuhiro Maeda, Osamu Higuchi, Tohru Okanishi, Yohei Kokudo, Kazushi Deguchi and 10 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
  3. Achalasia: The Current Clinical Dilemma and Possible Pathogenesis.Journal of neurogastroenterology and motility · 2023
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 9 institutions in 1 country.

Akihiro MukainoFirst Department of Internal Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Hitomi MinamiDepartment of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Hajime IsomotoDepartment of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Hitomi HamamotoDepartment of Human and Environmental Sciences, Digestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Eikichi IharaDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yasuhiro MaedaDepartment of Neuroimmunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Osamu HiguchiDepartment of Clinical Research, Nagasaki Kawatana Medical Center, 2005-1 Shimogumigo, Kawatanacho, Higashisonogigun, Nagasaki, 859-3615, Japan.
Tohru OkanishiDepartment of Child Neurology, Seirei Hamamatsu General Hospital, Shizuoka, Japan.
Yohei KokudoDepartment of Neurology, Kagawa University Hospital, Kagawa, Japan.
Kazushi DeguchiDepartment of Neurology, Kagawa University Hospital, Kagawa, Japan.
Fumisato SasakiDepartment of Human and Environmental Sciences, Digestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Toshihito UekiDepartment of Gastroenterology and Hepatology, Nagasaki Kawatana Medical Center, Nagasaki, Japan.
Ken-Ya MurataDepartment of Neurology, Wakayama Medical University, Wakayama, Japan.
Takeshi YoshidaDepartment of Medicine and Rheumatology, Okinawa Chubu Hospital, Uruma, Okinawa, Japan.
Mistuyo KinjoDepartment of Medicine and Rheumatology, Okinawa Chubu Hospital, Uruma, Okinawa, Japan.
Yoshihiro OgawaDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Akio IdoDepartment of Human and Environmental Sciences, Digestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Hidenori MatsuoDepartment of Neurology, Nagasaki Kawatana Medical Center, Nagasaki, Japan.
Kazuhiko NakaoDepartment of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Shunya NakaneDepartment of Neuroimmunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. nakaneshunya@gmail.com.ORCID http://orcid.org/0000-0003-1958-095X
Nagasaki Kawatana Medical Center · JPNagasaki University · JPKagoshima University · JPKagawa University Hospital · JPKyushu University · JPOkinawa Prefectural Chubu Hospital · JPSeirei Hamamatsu General Hospital · JPUniversity of Nagasaki · JPWakayama Medical University · JP

Funding

Japan Society for the Promotion of Science 25461305
6 · The paper itself

Abstract

backgroundThe existence of several autoantibodies suggests an autoimmune basis for gastrointestinal (GI) dysmotility. Whether GI motility disorders are features of autoimmune autonomic ganglionopathy (AAG) or are related to circulating anti-ganglionic acetylcholine receptor (gAChR) antibodies (Abs) is not known. The aim of this study was to determine the associations between autonomic dysfunction, anti-gAChR Abs, and clinical features in patients with GI motility disorders including achalasia and chronic intestinal pseudo-obstruction (CIPO).

methodsFirst study: retrospective cohort study and laboratory investigation. Samples from 123 patients with seropositive AAG were obtained between 2012 and 2017. Second study: prospective study. Samples from 28 patients with achalasia and 14 patients with CIPO were obtained between 2014 and 2016, and 2013 and 2017, respectively. In the first study, we analyzed clinical profiles of seropositive AAG patients. In the second study, we compared clinical profiles, autonomic symptoms, and results of antibody screening between seropositive, seronegative achalasia, and CIPO groups.

resultsIn the first study, we identified 10 patients (8.1%) who presented with achalasia, or gastroparesis, or paralytic ileus. In the second study, we detected anti-gAChR Abs in 21.4% of the achalasia patients, and in 50.0% of the CIPO patients. Although patients with achalasia and CIPO demonstrated widespread autonomic dysfunction, bladder dysfunction was observed in the seropositive patients with CIPO as a prominent clinical characteristic of dysautonomia.

conclusionsThese results demonstrate a significant prevalence of anti-gAChR antibodies in patients with achalasia and CIPO. Anti-gAChR Abs might mediate autonomic dysfunction, contributing to autoimmune mechanisms underlying these GI motility disorders.

Indexed as

AdultAgedAged, 80 and overAutoantibodiesAutoimmune DiseasesAutonomic Nervous System DiseasesChildChronic DiseaseCohort StudiesEsophageal AchalasiaFemaleGanglia, AutonomicGastrointestinal DiseasesGastrointestinal MotilityHumansIntestinal Pseudo-ObstructionAutoantibodiesReceptors, CholinergicAchalasiaAnti-ganglionic acetylcholine receptor (gAChR) antibodiesAutoimmune autonomic ganglionopathy (AAG)Autoimmune gastrointestinal dysmotility (AGID)Chronic intestinal pseudo-obstruction (CIPO)

Identifiers

PMID29766276
OpenAlexW2804324378

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.