Caution for chlorhexidine gluconate use for oral care: insufficient data.

Registry-linked trialAbstract readEditorialComment

In one paragraph

Article in Intensive care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04252469 (Efficacy of Pre-intubation Chlorhexidine Oral Care on Health Outcomes), which is not on this map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04252469 nacompletednot on this mapstarted 2019, after this paper: background citation

Efficacy of Pre-intubation Chlorhexidine Oral Care on Health Outcomes

TypeinterventionalSponsorNational Taiwan University HospitalRan2019 to 2019Enrolled210ConditionsIntratracheal Intubation, Surgery, AnesthesiaArmsOral care

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

Effect of chlorhexidine vs. saline for oral care on oral microbiota and prognosis of elderly mechanically ventilated patients in the intensive care unit: a single-center, single-blind, randomized controlled trial.BMC oral health · 2025
Trial
Predictors of self-reported practice in ventilator-associated pneumonia (VAP) prevention among critical care nurses in Sarawak public hospitals.PloS one · 2025
Article
Evaluation of ventilator-associated pneumonia care practice in the intensive care units of a comprehensive specialized hospital in Northwest Ethiopia: a 1.5-year prospective observational study.BMC anesthesiology · 2024
Observational
Pathogenesis-Targeted Preventive Strategies for Multidrug Resistant Ventilator-Associated Pneumonia: A Narrative Review.Microorganisms · 2020
Review
Oropharyngeal colonization: epidemiology, treatment and ventilator-associated pneumonia prevention.Annals of translational medicine · 2018
Review

4 · The record

Corrections and comments

Comment on
Effects of chlorhexidine gluconate oral care on hospital mortality: a hospital-wide, observational cohort study.2018

5 · Who and what money

Authors and funding

2 authors.

Jean-Damien RicardService de Réanimation Médico-Chirurgicale, Médecine Intensive et Réanimation, Hôpital Louis Mourier, AP-HP, 92700, Paris, Colombes, France. jean-damien.ricard@aphp.fr.ORCID 0000-0003-1828-2299

Thiago LisboaCritical Care Department and Infection Control Committee, Hospital de Clinicas de Porto Alegre, Rua Ramiro Barcelos, 2350, Porto Alegre, CEP 90035-903, Brazil. tlisboa@hcpa.edu.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anti-Infective Agents, LocalChlorhexidineAnti-Infective Agents, LocalChlorhexidinechlorhexidine gluconate

Identifiers

PMID29766214

DOI10.1007/s00134-018-5217-6

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

NCT04252469ClinicalTrials.gov

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.