Evidence map›Paper›PMID 29766040›Full record

ArticleeNeuro

The Midline Axon Crossing Decision Is Regulated through an Activity-Dependent Mechanism by the NMDA Receptor.

Jingxia Gao, Tamara J Stevenson, Adam D Douglass, Joshua P Barrios, Joshua L Bonkowsky

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jingxia GaoDepartment of Pediatrics.
Tamara J StevensonDepartment of Pediatrics.
Adam D DouglassDepartment of Neurobiology and Anatomy University of Utah School of Medicine Salt Lake City, Utah 84112.
Joshua P BarriosDepartment of Neurobiology and Anatomy University of Utah School of Medicine Salt Lake City, Utah 84112.
Joshua L BonkowskyDepartment of Pediatrics.ORCID 0000-0001-8775-147X
University of Utah · US

Funding

Trans-Cellular Activation of Transcription to Analyze Dopaminergic Axon ReorganizDP2MH100008 · NIMH · UNIVERSITY OF UTAH · PI BONKOWSKY, JOSH LEITCH · 2012 to 2012
$2.2M
Mechanisms of Serotonergic Regulation for Connectivity DevelopmentR21MH107039 · NIMH · UNIVERSITY OF UTAH · PI BONKOWSKY, JOSH LEITCH · 2015 to 2016
$410k
NIMH NIH HHS DP2 MH100008NIMH NIH HHS R21 MH107039
6 · The paper itself

Abstract

Axon guidance in vertebrates is controlled by genetic cascades as well as by intrinsic activity-dependent refinement of connections. Midline axon crossing is one of the best studied pathfinding models and is fundamental to the establishment of bilaterally symmetric nervous systems. However, it is not known whether crossing requires intrinsic activity in axons, and what controls that activity. Further, a mechanism linking neuronal activity and gene expression has not been identified for axon pathfinding. Using embryonic zebrafish, we found that the NMDA receptor (NMDAR) NR1.1 subunit (

Indexed as

AnimalsAnimals, Genetically ModifiedAxonsCentral Nervous SystemEmbryo, NonmammalianGene Expression Regulation, DevelopmentalHypoxiaReceptors, N-Methyl-D-AspartateZebrafishZebrafish ProteinsNR1 NMDA receptorReceptors, N-Methyl-D-AspartateZebrafish Proteinsactivityaxon pathfindinghypoxiamidlineNMDA receptorzebrafish

Identifiers

PMID29766040
PMCPMC5952305
OpenAlexW2802905100

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.