ArticleOpen forum infectious diseases2017
A Mycoses Study Group International Prospective Study of Phaeohyphomycosis: An Analysis of 99 Proven/Probable Cases.
Article in Open forum infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed.
- Dematiaceous Fungal Infections in Hematopoietic Stem Cell Transplantation and Predisposing Hematological Conditions: A Systematic Review.Journal of fungi (Basel, Switzerland) · 2026Review
- DisseminatedMedical mycology case reports · 2026Article
- A hospital-based retrospective study of hospitalizations with hyalohyphomycosis and phaeohyphomycosis in the United States.Lancet regional health. Americas · 2026Article
- Phaeohyphomycoses in kidney transplant recipients: A 10-year retrospective study from the French West Indies.Medical mycology · 2026Article
- Chromoblastomycosis and phaeohyphomycotic abscess-associated hospitalizations, United States, 2016-2021.PLoS neglected tropical diseases · 2025Article
- Phaeohyphomycosis due toMedical mycology case reports · 2025Article
- Chromoblastomycosis, Phaeohyphomycotic Abscess, and Sporotrichosis Among American Indian/Alaska Natives, Indian Health Service, 2016-2022.The American journal of tropical medicine and hygiene · 2025Article
- Rare mycetoma caused byIDCases · 2025Article
- Nomenclature for human and animal fungal pathogens and diseases: a proposal for standardized terminology.Journal of clinical microbiology · 2024Review
- The Brief Case: Hidden in plain sight-Journal of clinical microbiology · 2024Review
- Phaeohyphomycosis Due to Verruconis gallopava: Rare Indolent Pulmonary Infection or Severe Cerebral Fungal Disease?Mycopathologia · 2024Review
- Article
- Meeting the Therapeutic Challenges of Emergent and Rare Invasive Fungal Diseases Through Novel Clinical Trial Designs.Open forum infectious diseases · 2024Review
- Chemotherapy Extravasation Causing Soft-Tissue Necrosis Mimicking Infection: A Longitudinal Case Study.Cureus · 2024Article
- Trans-kingdom fungal pathogens infecting both plants and humans, and the problem of azole fungicide resistance.Frontiers in microbiology · 2024Review
- Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management.Clinical microbiology reviews · 2023Review
- Race and ethnicity: Risk factors for fungal infections?PLoS pathogens · 2023Review
- Human Dectin-1 deficiency impairs macrophage-mediated defense against phaeohyphomycosis.The Journal of clinical investigation · 2022Article
- Tender violaceous nodule on the palm.JAAD case reports · 2022Article
- Invasive Rhinosinusitis Caused byJournal of fungi (Basel, Switzerland) · 2022Article
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21 authors.
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Abstract
backgroundPhaeohyphomycosis is infection caused by dematiaceous, or darkly pigmented, fungi. The spectrum of disease is broad, and optimal therapy remains poorly defined. The Mycoses Study Group established an international case registry of patients with proven/probable phaeohyphomycosis with the goal of improving the recognition and management of these infections.
methodsPatients from 18 sites in 3 countries were enrolled from 2009-2015. Cases were categorized as local superficial, local deep (pulmonary, sinus, osteoarticular infections), and disseminated infections. End points were clinical response (partial and complete) and all-cause mortality at 30 days and end of follow-up.
resultsOf 99 patients, 32 had local superficial infection, 41 had local deep infection, and 26 had disseminated infection. The most common risk factors were corticosteroids, solid organ transplantation, malignancy, and diabetes. Cultures were positive in 98% of cases. All-cause mortality was 16% at 30 days and 33% at end of follow-up, and 18 of 26 (69%) with dissemination died. Itraconazole was most commonly used for local infections, and voriconazole was used for more severe infections, often in combination with terbinafine or amphotericin B.
conclusionsPhaeohyphomycosis is an increasingly recognized infection. Culture remains the most frequently used diagnostic method. Triazoles are currently the drugs of choice, often combined with other agents. Further studies are needed to develop optimal therapies for disseminated infections.
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