Evidence map›Paper›PMID 29765956›Full record

ArticleFrontiers in cell and developmental biology2018

Transcriptomic Profiling of Zebrafish Hair Cells Using RiboTag.

Maggie S Matern, Alisha Beirl, Yoko Ogawa, Yang Song, Nikhil Paladugu, Katie S Kindt, Ronna Hertzano

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
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  8. How Zebrafish Can Drive the Future of Genetic-based Hearing and Balance Research.Journal of the Association for Research in Otolaryngology : JARO · 2021
    Review
  9. Article
  10. Unraveling the Molecular Players at the Cholinergic Efferent Synapse of the Zebrafish Lateral Line.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  11. Review
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  19. Article
  20. Transmission Disrupted: Modeling Auditory Synaptopathy in Zebrafish.Frontiers in cell and developmental biology · 2018
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Maggie S MaternDepartment of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD, United States.
Alisha BeirlSection on Sensory Cell Development and Function, National Institute on Deafness and Other Communication Disorders, Bethesda, MD, United States.
Yoko OgawaDepartment of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD, United States.
Yang SongInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, United States.
Nikhil PaladuguDepartment of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD, United States.
Katie S KindtSection on Sensory Cell Development and Function, National Institute on Deafness and Other Communication Disorders, Bethesda, MD, United States.
Ronna HertzanoDepartment of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD, United States.
University of Maryland, Baltimore · USNational Institute on Deafness and Other Communication Disorders · US

Funding

In vivo investigation of sensory hair cell function and developmentZIADC000085 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI KINDT, KATIE · 2014 to 2025
$21.4M
AUTOSOMAL DOMINANT NONSYNDROMIC HEARING LOSSR01DC003544 · NIDCD · UNIVERSITY OF IOWA · PI SMITH, RICHARD J.H. · 1998 to 2017
$7.8M
COMPARATIVE AND EVOLUTIONARY BIOLOGY OF HEARINGT32DC000046 · NIDCD · UNIV OF MARYLAND, COLLEGE PARK · PI Catherine Emily Carr, Matthew J. Goupell · 1994 to 2026
$7.5M
Cell Type Specific Transcriptional Cascades in Inner Ear DevelopmentR01DC013817 · NIDCD · UNIVERSITY OF MARYLAND BALTIMORE · PI HERTZANO, RONNA · 2015 to 2022
$3.6M
Linkage/Positional Cloning In Communication DisordersZ01DC000046 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI DRAYNA, DENNIS · 1998 to 2008
$3.3M
Cell Type Specific Transcriptional Cascades in Inner Ear DevelopmentU01DC013817 · NIDCD · UNIVERSITY OF MARYLAND BALTIMORE · PI AHMED, ZUBAIR M. · 2023 to 2025
$1.6M
To be or not to be_GFI1 as a critical factor in hair cell fate and survivalF31DC016218 · NIDCD · UNIVERSITY OF MARYLAND BALTIMORE · PI MATERN, MAGGIE S. · 2017 to 2018
$60k
Intramural NIH HHS Z01 DC000046Intramural NIH HHS ZIA DC000085NIDCD NIH HHS F31 DC016218NIDCD NIH HHS R01 DC003544NIDCD NIH HHS R01 DC013817NIDCD NIH HHS T32 DC000046NIDCD NIH HHS U01 DC013817
6 · The paper itself

Abstract

The zebrafish inner ear organs and lateral line neuromasts are comprised of a variety of cell types, including mechanosensitive hair cells. Zebrafish hair cells are evolutionarily homologous to mammalian hair cells, and have been particularly useful for studying normal hair cell development and function. However, the relative scarcity of hair cells within these complex organs, as well as the difficulty of fine dissection at early developmental time points, makes hair cell-specific gene expression profiling technically challenging. Cell sorting methods, as well as single-cell RNA-Seq, have proved to be very informative in studying hair cell-specific gene expression. However, these methods require that tissues are dissociated, the processing for which can lead to changes in gene expression prior to RNA extraction. To bypass this problem, we have developed a transgenic zebrafish model to evaluate the translatome of the inner ear and lateral line hair cells in their native tissue environment; the

Indexed as

hair cellsinner earRiboTagRNA-Seqzebrafish

Identifiers

PMID29765956
PMCPMC5939014
OpenAlexW2802004472

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.