Evidence map›Paper›PMID 29765907›Full record

ArticleFrontiers in oncology2018

Attenuated Bacteria as Immunotherapeutic Tools for Cancer Treatment.

Suneesh Kaimala, Ashraf Al-Sbiei, Otavio Cabral-Marques, Maria J Fernandez-Cabezudo, Basel K Al-Ramadi

Abstract read
In one paragraph

Article in Frontiers in oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Review
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  3. Review
  4. AttenuatedFrontiers in immunology · 2026
    Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Metagenomic shotgun sequencing reveals the enrichment ofComputational and structural biotechnology journal · 2024
    Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Culture of attenuatedHuman vaccines & immunotherapeutics · 2023
    Article
  15. Current advances in microbial-based cancer therapies.Medical oncology (Northwood, London, England) · 2023
    Review
  16. Acta biochimica et biophysica Sinica · 2023
    Review
  17. Pharmaceutics · 2022
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Suneesh KaimalaDepartment of Medical Microbiology and Immunology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
Ashraf Al-SbieiDepartment of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
Otavio Cabral-MarquesCenter for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Maria J Fernandez-CabezudoDepartment of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
Basel K Al-RamadiDepartment of Medical Microbiology and Immunology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of attenuated bacteria as cancer therapeutic tools has garnered increasing scientific interest over the past 10 years. This is largely due to the development of bacterial strains that maintain good anti-tumor efficacy, but with reduced potential to cause toxicities to the host. Because of its ability to replicate in viable as well as necrotic tissue, cancer therapy using attenuated strains of facultative anaerobic bacteria, such as

Indexed as

attenuated Salmonellabacterial therapycancer immunotherapymyeloid-derived suppressor cellstumor-infiltrating leukocytestumor microenvironment

Identifiers

PMID29765907
PMCPMC5938341

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.