Evidence map›Paper›PMID 29765865›Full record

ArticleMetabolic engineering communications2018

A protocatechuate biosensor for

Ramesh K Jha, Jeremy M Bingen, Christopher W Johnson, Theresa L Kern, Payal Khanna, Daniel S Trettel, Charlie E M Strauss, Gregg T Beckham, Taraka Dale

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolic engineering communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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  12. Outer membrane vesicles catabolize lignin-derived aromatic compounds inProceedings of the National Academy of Sciences of the United States of America · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ramesh K JhaBioscience Division, MS M888, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Jeremy M BingenBioscience Division, MS M888, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Christopher W JohnsonNational Bioenergy Center, National Renewable Energy Laboratory, Golden, CO 80401, USA.
Theresa L KernBioscience Division, MS M888, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Payal KhannaNational Bioenergy Center, National Renewable Energy Laboratory, Golden, CO 80401, USA.
Daniel S TrettelBioscience Division, MS M888, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Charlie E M StraussBioscience Division, MS M888, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Gregg T BeckhamNational Bioenergy Center, National Renewable Energy Laboratory, Golden, CO 80401, USA.
Taraka DaleBioscience Division, MS M888, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Robust fluorescence-based biosensors are emerging as critical tools for high-throughput strain improvement in synthetic biology. Many biosensors are developed in model organisms where sophisticated synthetic biology tools are also well established. However, industrial biochemical production often employs microbes with phenotypes that are advantageous for a target process, and biosensors may fail to directly transition outside the host in which they are developed. In particular, losses in sensitivity and dynamic range of sensing often occur, limiting the application of a biosensor across hosts. Here we demonstrate the optimization of an

Indexed as

Aromatic catabolismPcaUShikimateTranscription factorWhole cell biosensor

Identifiers

PMID29765865
PMCPMC5949891

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.