ArticleBrain plasticity (Amsterdam, Netherlands)2015
Running Improves Pattern Separation during Novel Object Recognition.
Article in Brain plasticity (Amsterdam, Netherlands), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 80 citations in OpenAlex.
- Long-Term Effects of a 5-Year Randomized Controlled Exercise Trial on Brain Volumes and Cognitive Function in Older Adults: A 4-Year Post-Intervention Follow-Up Study.Sports medicine (Auckland, N.Z.) · 2026Trial
- Voluntary Long-Term Exercise by Female Mice Modulates Anxiety-Like Behavior and Motor Function but Minimally Impacts Acute Oxidative Injury in the Central Nervous System.The European journal of neuroscience · 2025Article
- Current Strategies for Healthy Aging: The Interplay Between Nutrition, Metabolism, and Exercise.Cureus · 2025Review
- Hippocampal Neurogenesis via Light-Intensity Running and Its Mechanism.Advances in neurobiology · 2025Review
- The impact of adult neurogenesis on affective functions: of mice and men.Molecular psychiatry · 2024Review
- Face-valid phenotypes in a mouse model of the most common mutation in EEF1A2-related neurodevelopmental disorder.Disease models & mechanisms · 2024Article
- Exercised blood plasma promotes hippocampal neurogenesis in the Alzheimer's disease rat brain.Journal of sport and health science · 2024Article
- Exercise and Fear and Safety Learning.Current topics in behavioral neurosciences · 2024Review
- Scopolamine-Induced Memory Impairment in Mice: Effects of PEA-OXA on Memory Retrieval and Hippocampal LTP.International journal of molecular sciences · 2023Article
- Effects of acute aerobic exercise on mnemonic discrimination performance in older adults.Journal of the International Neuropsychological Society : JINS · 2023Article
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- Protective role of cod liver oil on hippocampal oxidative damage and neuronal count in Wistar rat model of comorbid depression.Open veterinary journal · 2023Article
- Aerobic exercise in the treatment of PTSD: An examination of preclinical and clinical laboratory findings, potential mechanisms, clinical implications, and future directions.Journal of anxiety disorders · 2023Review
- Adult-born neurons add flexibility to hippocampal memories.Frontiers in neuroscience · 2023Review
- Evaluation of delayed LNFPIII treatment initiation protocol on improving long-term behavioral and neuroinflammatory pathology in a mouse model of Gulf War Illness.Brain, behavior, & immunity - health · 2022Article
- Moderate effect of early-life experience on dentate gyrus function.Molecular brain · 2022Article
- Short-Term, Voluntary Exercise Affects Morpho-Functional Maturation of Adult-Generated Neurons in Rat Hippocampus.International journal of molecular sciences · 2022Article
- Article
- Complicated Role of Exercise in Modulating Memory: A Discussion of the Mechanisms Involved.Neurochemical research · 2022Review
- Spiking Neural Networks and Hippocampal Function: A Web-Accessible Survey of Simulations, Modeling Methods, and Underlying Theories.Cognitive systems research · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Running increases adult neurogenesis and improves pattern separation in various memory tasks including context fear conditioning or touch-screen based spatial learning. However, it is unknown whether pattern separation is improved in spontaneous behavior, not emotionally biased by positive or negative reinforcement. Here we investigated the effect of voluntary running on pattern separation during novel object recognition in mice using relatively similar or substantially different objects.We show that running increases hippocampal neurogenesis but does not affect object recognition memory with 1.5 h delay after sample phase. By contrast, at 24 h delay, running significantly improves recognition memory for similar objects, whereas highly different objects can be distinguished by both, running and sedentary mice. These data show that physical exercise improves pattern separation, independent of negative or positive reinforcement. In sedentary mice there is a pronounced temporal gradient for remembering object details. In running mice, however, increased neurogenesis improves hippocampal coding and temporally preserves distinction of novel objects from familiar ones.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.