ReviewBrain plasticity (Amsterdam, Netherlands)2015
The Benefits of Exercise on Structural and Functional Plasticity in the Rodent Hippocampus of Different Disease Models.
Review in Brain plasticity (Amsterdam, Netherlands), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed.
- Bioactive compounds and exercise in aging and neurodegeneration: mechanistic insights from the gut-brain-metabolic axis.Frontiers in nutrition · 2026Review
- In Vivo Quantification of White Matter Pathways in the Human Hippocampus.Human brain mapping · 2025Article
- The interplay between physical exercise and autophagy signaling in brain health, neurodegenerative diseases and aging.Frontiers in aging neuroscience · 2025Review
- The impact of adult neurogenesis on affective functions: of mice and men.Molecular psychiatry · 2024Review
- Treadmill exercise pretreatment ameliorated structural synaptic plasticity impairments of medial prefrontal cortex in vascular dementia rat and improved recognition memory.Scientific reports · 2024Article
- Neurogranin as an important regulator in swimming training to improve the spatial memory dysfunction of mice with chronic cerebral hypoperfusion.Journal of sport and health science · 2023Article
- Temporal endurance of exercise-induced benefits on hippocampus-dependent memory and synaptic plasticity in female mice.Neurobiology of learning and memory · 2022Article
- Review
- Basal Forebrain Impairment: Understanding the Mnemonic Function of the Septal Region Translates in Therapeutic Advances.Frontiers in neural circuits · 2022Review
- Cardiovascular fitness and structural brain integrity: an update on current evidence.GeroScience · 2020Review
- Sex-Specific Relationship Between Long-Term Maintenance of Physical Activity and Cognition in the Health ABC Study: Potential Role of Hippocampal and Dorsolateral Prefrontal Cortex Volume.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Aging Alters Olfactory Bulb Network Oscillations and Connectivity: Relevance for Aging-Related Neurodegeneration Studies.Neural plasticity · 2020Article
- Clmp Regulates AMPA and Kainate Receptor Responses in the Neonatal Hippocampal CA3 and Kainate Seizure Susceptibility in Mice.Frontiers in synaptic neuroscience · 2020Article
- Impacts of exercise interventions on different diseases and organ functions in mice.Journal of sport and health science · 2020Review
- Higher Cardiorespiratory Fitness is Associated with Reduced Functional Brain Connectivity During Performance of the Stroop Task.Brain plasticity (Amsterdam, Netherlands) · 2019Article
- Comparative benefits of simvastatin and exercise in a mouse model of vascular cognitive impairment and dementia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Long-term obesogenic diet and targeted deletion of potassium channel KPhysiological reports · 2019Article
- Paradoxical effects of exercise on hippocampal plasticity and cognition in mice with a heterozygous null mutation in the serotonin transporter gene.British journal of pharmacology · 2019Article
- Acute slice preparation for electrophysiology increases spine numbers equivalently in the male and female juvenile hippocampus: a DiI labeling study.Journal of neurophysiology · 2019Article
- Physical Activity Alleviates Cognitive Dysfunction of Alzheimer's Disease through Regulating the mTOR Signaling Pathway.International journal of molecular sciences · 2019Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this review, the benefits of physical exercise on structural and functional plasticity in the hippocampus are discussed. The evidence is clear that voluntary exercise in rats and mice can lead to increases in hippocampal neurogenesis and enhanced synaptic plasticity which ultimately result in improved performance in hippocampal-dependent tasks. Furthermore, in models of neurological disorders, including fetal alcohol spectrum disorders, traumatic brain injury, stroke, and neurodegenerative disorders including Alzheimer's, Parkinson's and Huntington's disease exercise can also elicit beneficial effects on hippocampal function. Ultimately this review highlights the multiple benefits of exercise on hippocampal function in both the healthy and the diseased brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.