ArticleRoyal Society open science2018
Analytical model of the feto-placental vascular system: consideration of placental oxygen transport.
Article in Royal Society open science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- A flexible generative algorithm for growing in silico placentas.PLoS computational biology · 2024Article
- A review of feto-placental vasculature flow modelling.Placenta · 2023Review
- Multi-scale Modelling of Shear Stress on the Syncytiotrophoblast: Could Maternal Blood Flow Impact Placental Function Across Gestation?Annals of biomedical engineering · 2023Article
- Feto-placental Unit: From Development to Function.Advances in experimental medicine and biology · 2023Review
- Bioengineering Approaches for Placental Research.Annals of biomedical engineering · 2021Review
- Biomechanics of Human Fetal Hearts with Critical Aortic Stenosis.Annals of biomedical engineering · 2021Article
- The placental transcriptome of the first-trimester placenta is affected by in vitro fertilization and embryo transfer.Reproductive biology and endocrinology : RB&E · 2019Article
- Nutrient sensor signaling pathways and cellular stress in fetal growth restriction.Journal of molecular endocrinology · 2019Review
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
The placenta is a transient vascular organ that enables nutrients and blood gases to be exchanged between fetal and maternal circulations. Herein, the structure and oxygen diffusion across the trophoblast membrane between the fetal and maternal red blood cells in the feto-placental vasculature system in both human and mouse placentas are presented together as a functional unit. Previous models have claimed that the most efficient fetal blood flow relies upon structures containing a number of 'conductive' symmetrical branches, offering a path of minimal resistance that maximizes blood flow to the terminal villi, where oxygen diffusion occurs. However, most of these models have disregarded the actual descriptions of the exchange at the level of the intermediate and terminal villi. We are proposing a 'mixed model' whereby both 'conductive' and 'terminal' villi are presumed to be present at the end of single (in human) or multiple (in mouse) pregnancies. We predict an optimal number of 18 and 22 bifurcation levels in the human and the mouse placentas, respectively. Wherever possible, we have compared our model's predictions with experimental results reported in the literature and found close agreement between them.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.