ArticleElectronic physician2018
Association of serum testosterone and dehydroepiandrosterone sulfate with rheumatoid arthritis: a case control study.
Article in Electronic physician, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Reproductive Effect by Rheumatoid Arthritis and Related Autoantibodies.Rheumatology and therapy · 2024Review
- Lower serum testosterone is associated with increased likelihood of arthritis.Scientific reports · 2023Article
- Dehydroepiandrosterone (DHEA) Supplementation in Rheumatic Diseases: A Systematic Review.Mediterranean journal of rheumatology · 2023Article
- Cumulative physiological stress is associated with age-related changes to peripheral T lymphocyte subsets in healthy humans.Immunity & ageing : I & A · 2023Article
- Organokines in Rheumatoid Arthritis: A Critical Review.International journal of molecular sciences · 2022Review
- Androgens, Endometriosis and Pain.Frontiers in reproductive health · 2021Review
- Dehydroepiandrostenedione sulphate (DHEAS) levels predict high risk of rheumatoid arthritis (RA) in subclinical hypothyroidism.PloS one · 2021Article
- Article
- The Potential Effect of Aberrant Testosterone Levels on Common Diseases: A Mendelian Randomization Study.Genes · 2020Article
- Autoimmune Hashimoto's Disease and Feminization Level-TestingEvolutionary psychology : an international journal of evolutionary approaches to psychology and behaviorArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is supposed that hypoandrogenism may be involved in the pathogenesis of rheumatoid arthritis (RA). Testosterone and dehydroepiandrosterone sulfate (DHEAs) levels decrease in body fluids of patients with RA.
objectiveThe aim of this study was to determine the association of serum testosterone and DHEAs with RA.
methodsThis case-control study was conducted on 59 patients with RA and 61 healthy gender- and age-matched controls at Qazvin University of Medical Sciences, Qazvin, Iran, in 2014. Serum free testosterone and DHEAs levels were measured and compared between two groups. Serum testosterone levels lower than 0.029 ng/ml in females and 2.49 ng/ml in males were considered as abnormal. DHEAs levels lower than 18.9 μg/dl in females and 88.9 μg/dl in males were considered as abnormal. Data were analyzed using independent sample T-test, Chi-square test, and logistic regression analysis by SPSS software, version 19.
resultsThe mean testosterone level in females of the control group was significantly higher than females in the case group. The mean DHEAs in the control group was significantly higher than the case group. Abnormal testosterone and DHEAs level in the case group was significantly higher than the control group. Logistic regression analysis showed independent association only between DHEAs levels and RA, after adjusting for age and gender (OR: 0.966, 95% CI: 0.953-0.979; p<0.001).
conclusionWith regard to the results, abnormal testosterone and DHEAs level in patients with RA was significantly higher than the control group. This shows the anti-inflammatory effects of gonadal and adrenal androgens in RA.
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