Evidence map›Paper›PMID 29765549›Full record

ArticleOncotarget2018

Deregulation of methylation of transcribed-ultra conserved regions in colorectal cancer and their value for detection of adenomas and adenocarcinomas.

Anastasia E Kottorou, Anna G Antonacopoulou, Foteinos-Ioannis D Dimitrakopoulos, Georgia Diamantopoulou, Chaido Sirinian, Melpomeni Kalofonou, Theodoros Theodorakopoulos, Chrysa Oikonomou, Evangelos C Katsakoulis, Angelos Koutras and 6 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Anastasia E KottorouClinical and Molecular Oncology Laboratory, Division of Oncology, Medical School, University of Patras, Patras, Greece.
Anna G AntonacopoulouClinical and Molecular Oncology Laboratory, Division of Oncology, Medical School, University of Patras, Patras, Greece.
Foteinos-Ioannis D DimitrakopoulosClinical and Molecular Oncology Laboratory, Division of Oncology, Medical School, University of Patras, Patras, Greece.
Georgia DiamantopoulouDivision of Gastroenterology, University Hospital of Patras, Patras, Greece.
Chaido SirinianClinical and Molecular Oncology Laboratory, Division of Oncology, Medical School, University of Patras, Patras, Greece.
Melpomeni KalofonouClinical and Molecular Oncology Laboratory, Division of Oncology, Medical School, University of Patras, Patras, Greece.
Theodoros TheodorakopoulosDivision of Gastroenterology, University Hospital of Patras, Patras, Greece.
Chrysa OikonomouDivision of Oncology, University Hospital of Patras, Patras, Greece.
Evangelos C KatsakoulisDivision of Gastroenterology, University Hospital of Patras, Patras, Greece.
Angelos KoutrasClinical and Molecular Oncology Laboratory, Division of Oncology, Medical School, University of Patras, Patras, Greece.
Thomas MakatsorisClinical and Molecular Oncology Laboratory, Division of Oncology, Medical School, University of Patras, Patras, Greece.
Nikos DemopoulosDivision of Genetics, Cell and Developmental Biology, Department of Biology, University of Patras, Patras, Greece.
Georgia StephanouDivision of Genetics, Cell and Developmental Biology, Department of Biology, University of Patras, Patras, Greece.
Michalis StavropoulosDepartment of Surgery, Medical School, University of Patras, Patras, Greece.
Konstantinos C ThomopoulosDivision of Gastroenterology, University Hospital of Patras, Patras, Greece.
Haralabos P KalofonosClinical and Molecular Oncology Laboratory, Division of Oncology, Medical School, University of Patras, Patras, Greece.
General University Hospital of Patras · GRUniversity of Patras · GRNIHR Imperial Biomedical Research Centre · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Expression of Transcribed Ultraconserved Regions (T-UCRs) is often deregulated in cancer. The present study assesses the expression and methylation of three T-UCRs (Uc160, Uc283 and Uc346) in colorectal cancer (CRC) and explores the potential of T-UCR methylation in circulating DNA for the detection of adenomas and adenocarcinomas. Expression levels of Uc160, Uc283 and Uc346 were lower in neoplastic tissues from 64 CRC patients (statistically significant for Uc160,

Indexed as

colorectal cancer and adenomasexpression levelsscreening biomarkertissue and plasma methylationtranscribed-ultra conserved regions

Identifiers

PMID29765549
PMCPMC5940382
OpenAlexW2802892684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.