ArticleScientific reports2018
Intrauterine smoke exposure deregulates lung function, pulmonary transcriptomes, and in particular insulin-like growth factor (IGF)-1 in a sex-specific manner.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Sex-specific in utero reprogramming of lung immunity.Mucosal immunology · 2026Article
- Developmental Impact of Maternal Immune Activation on the Fetal Immune System and Lung.European journal of immunology · 2026Review
- Maternal nutrition and offspring lung health: sex-specific pathway modulation in fibrosis, metabolism, and immunity.Food & nutrition research · 2025Article
- The Untapped Biomarker Potential of MicroRNAs for Health Risk-Benefit Analysis of Vaping vs. Smoking.Cells · 2024Review
- Intrauterine Smoke Exposure, microRNA Expression during Human Lung Development, and Childhood Asthma.International journal of molecular sciences · 2023Article
- Sex-Specific Alterations of the Lung Transcriptome at Birth in Mouse Offspring Prenatally Exposed to Vanilla-Flavored E-Cigarette Aerosols and Enhanced Susceptibility to Asthma.International journal of environmental research and public health · 2023Article
- Maternal vitamin D status modifies the effects of early life tobacco exposure on child lung function.The Journal of allergy and clinical immunology · 2023Article
- Identification of the key genes in chronic obstructive pulmonary disease by weighted gene co-expression network analysis.Annals of translational medicine · 2022Article
- Sex Differences in Airway Remodeling and Inflammation: Clinical and Biological Factors.Frontiers in allergy · 2022Review
- Fetal Programming: Lung Health and Disease.Turkish thoracic journal · 2021Article
- Spotlight on microRNAs in allergy and asthma.Allergy · 2021Review
- Prenatal smoke exposure induces persistentEpigenetics · 2020Article
- Spatiotemporal association of low birth weight with Cs-137 deposition at the prefecture level in Japan after the Fukushima nuclear power plant accidents: an analytical-ecologic epidemiological study.Environmental health : a global access science source · 2020Article
- Associations between Maternal and Fetal Levels of Total Adiponectin, High Molecular Weight Adiponectin, Selected Somatomedins, and Birth Weight of Infants of Smoking and Non-Smoking Mothers.International journal of environmental research and public health · 2020Article
- Diabetic vasculopathy: macro and microvascular injury.Current pathobiology reports · 2020Article
- Epigenetic impacts of maternal tobacco and e-vapour exposure on the offspring lung.Clinical epigenetics · 2019Review
- Cytokines and Chemokines as Biomarkers of Future Asthma.Frontiers in pediatrics · 2019Review
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prenatal exposure to tobacco smoke is a significant risk-factor for airway disease development. Furthermore, the high prevalence of pregnant smoking women requires the establishment of strategies for offspring lung protection. Therefore, we here aimed to understand the molecular mechanism of how prenatal smoke exposure affects fetal lung development. We used a mouse model recapitulating clinical findings of prenatally exposed children, where pregnant mice were exposed to smoke until c-section or spontaneous delivery, and offspring weight development and lung function was monitored. Additionally, we investigated pulmonary transcriptome changes in fetal lungs (GD18.5) by mRNA/miRNA arrays, network analyses and qPCR. The results demonstrated that prenatally exposed mice showed intrauterine and postnatal growth retardation, and impaired lung function. 1340 genes and 133 miRNAs were found to be significantly dysregulated by in utero smoke exposure, and we identified Insulin-like growth factor 1 (Igf1) as a top hierarchical node in a network analysis. Moreover, Igf1 mRNA was increased in female murine offspring and in prenatally exposed children. These findings suggest that prenatal smoking is associated with a dysregulation of several genes, including Igf1 in a sex-specific manner. Thus, our results could represent a novel link between smoke exposure, abberant lung development and impaired lung function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.