ArticleScientific reports2018
FABRICA: A Bioreactor Platform for Printing, Perfusing, Observing, & Stimulating 3D Tissues.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- From microtissues to macro solutions - The future of scalable and automated cartilage tissue engineering.Journal of orthopaedic translation · 2026Review
- Bioprinting Organs-Science or Fiction?-A Review From Students to Students.Advanced healthcare materials · 2026Review
- Reconstructing Liver Fibrosis: 3D Human Models, Microbiome Interfaces, and Therapeutic Innovation.Current issues in molecular biology · 2026Review
- 3D-printed constructs deliver bioactive cargos to expedite cartilage regeneration.Journal of pharmaceutical analysis · 2024Review
- Article
- The 'bIUreactor': An Open-Source 3D Tissue Research Platform.Annals of biomedical engineering · 2024Article
- Large-scale perfused tissues via synthetic 3D soft microfluidics.Nature communications · 2023Article
- Hep3Gel: A Shape-Shifting Extracellular Matrix-Based, Three-Dimensional Liver Model Adaptable to Different Culture Systems.ACS biomaterials science & engineering · 2023Article
- Article
- 3D printing biocompatible materials with Multi Jet Fusion for bioreactor applications.International journal of bioprinting · 2023Article
- An automated 3D-printed perfusion bioreactor combinable with pulsed electromagnetic field stimulators for bone tissue investigations.Scientific reports · 2022Article
- A Comprehensive Assessment on the Pivotal Role of Hydrogels in Scaffold-Based Bioprinting.Gels (Basel, Switzerland) · 2022Review
- Bioreactor design and validation for manufacturing strategies in tissue engineering.Bio-design and manufacturing · 2022Article
- Applications of 3D Bioprinting in Tissue Engineering and Regenerative Medicine.Journal of clinical medicine · 2021Review
- Designing and validation of an automated ex-vivo bioreactor system for long term culture of bone.Bone reports · 2021Article
- Regenerative medicine for skeletal muscle loss: a review of current tissue engineering approaches.Journal of materials science. Materials in medicine · 2021Review
- Three-Dimensional Biofabrication Models of Endometriosis and the Endometriotic Microenvironment.Biomedicines · 2020Article
- Unification of aggregate growth models by emergence from cellular and intracellular mechanisms.Royal Society open science · 2020Article
- Computational fluid dynamic analysis of bioprinted self-supporting perfused tissue models.Biotechnology and bioengineering · 2020Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
We are introducing the FABRICA, a bioprinter-agnostic 3D-printed bioreactor platform designed for 3D-bioprinted tissue construct culture, perfusion, observation, and analysis. The computer-designed FABRICA was 3D-printed with biocompatible material and used for two studies: (1) Flow Profile Study: perfused 5 different media through a synthetic 3D-bioprinted construct and ultrasonically analyzed the flow profile at increasing volumetric flow rates (VFR); (2) Construct Perfusion Study: perfused a 3D-bioprinted tissue construct for a week and compared histologically with a non-perfused control. For the flow profile study, construct VFR increased with increasing pump VFR. Water and other media increased VFR significantly while human and pig blood showed shallow increases. For the construct perfusion study, we confirmed more viable cells in perfused 3D-bioprinted tissue compared to control. The FABRICA can be used to visualize constructs during 3D-bioprinting, incubation, and to control and ultrasonically analyze perfusion, aseptically in real-time, making the FABRICA tunable for different tissues.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.