SynthesisProceedings of the National Academy of Sciences of the United States of America2018
Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium.
Synthesis in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 208 papers, 9 of them syntheses that pooled it.
What it found
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Who cites it
208 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- A meta-analysis of cognitive flexibility in aging: Perspective from functional network and lateralization.Human brain mapping · 2024Pooled it
- Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes.Nature genetics · 2023Pooled it
- Significant heterogeneity in structural asymmetry of the habenula in the human brain: A systematic review and meta-analysis.Human brain mapping · 2023Pooled it
- White matter variability, cognition, and disorders: a systematic review.Brain structure & function · 2022Pooled it
- Gray matter asymmetry in asymptomatic carotid stenosis.Human brain mapping · 2021Pooled it
- [Research progress on genetic effects of the asymmetry of human brain structure revealed by magnetic resonance imaging].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Pooled it
- Hubs of long-distance co-alteration characterize brain pathology.Human brain mapping · 2020Pooled it
- Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium.Biological psychiatry · 2020Pooled it
- ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries.Translational psychiatry · 2020Pooled it
- Cerebral cortical alterations in adolescent early-onset psychosis: a surface-based morphometry mega-analysis.Molecular psychiatry · 2026Article
- Orbitofrontal and Medial Frontal Gray Matter Volumes Are Associated With Hyperactivity Traits in 2548 Nonclinical Adults.Human brain mapping · 2026Article
- Quantifying extra-lesional interhemispheric cortical asymmetry in focal cortical dysplasia type II.Epilepsia open · 2026Article
- Motifs of brain cortical folding from birth to adulthood.Nature communications · 2026Article
- Magnetic Resonance Imaging-Based Cortical and Subcortical Volumetric Changes in Alzheimer's Disease: Association with Clinical Severity.Diagnostics (Basel, Switzerland) · 2026Article
- Region-specific demographic determinants and hemispheric asymmetry of perivascular space burden in healthy adults: a quantitative 3T neuroimaging study.Neuroradiology · 2026Article
- Variations of global brain asymmetry are associated with aging and related diseases.Science advances · 2026Article
- Age dependence of brain oxygen metabolism in adults assessed by 3D constrained quantitative BOLD MRI.NeuroImage · 2026Article
- Lifespan Trajectories of Asymmetry in White Matter Tracts.Human brain mapping · 2026Article
- Intergenerational transmission of the structure of the auditory cortex and reading skills.Developmental cognitive neuroscience · 2026Article
- Personalized Estimates of Brain Cortical Structural Similarity in Major Depressive Disorder: Evidence from a Multi-Site Neuroimaging Dataset.Diagnostics (Basel, Switzerland) · 2026Article
148 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Hemispheric asymmetry is a cardinal feature of human brain organization. Altered brain asymmetry has also been linked to some cognitive and neuropsychiatric disorders. Here, the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium presents the largest-ever analysis of cerebral cortical asymmetry and its variability across individuals. Cortical thickness and surface area were assessed in MRI scans of 17,141 healthy individuals from 99 datasets worldwide. Results revealed widespread asymmetries at both hemispheric and regional levels, with a generally thicker cortex but smaller surface area in the left hemisphere relative to the right. Regionally, asymmetries of cortical thickness and/or surface area were found in the inferior frontal gyrus, transverse temporal gyrus, parahippocampal gyrus, and entorhinal cortex. These regions are involved in lateralized functions, including language and visuospatial processing. In addition to population-level asymmetries, variability in brain asymmetry was related to sex, age, and intracranial volume. Interestingly, we did not find significant associations between asymmetries and handedness. Finally, with two independent pedigree datasets (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.