ArticleThe EMBO journal2018
Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis.
Open access · hybridAbstract read
In one paragraph
Article in The EMBO journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.
0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed
14.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
105 citing papers in PubMed, 182 citations in OpenAlex.
- Human TDP-43 expression worsens FTD-related phenotypes in progranulin-insufficient mice.Neurobiology of disease · 2026Article
- TDP-43 controls RNA structure through high affinity lattice interactions.Nature communications · 2026Article
- TDP-43 proteinopathy as a biomarker and therapeutic target in amyotrophic lateral sclerosis.Biochemical Society transactions · 2026Review
- Pathogenicity Classification ofCells · 2026Article
- Isoform-specific steric zippers drive aberrant assembly and mislocalization of shortened TDP-43.Science advances · 2026Article
- Long-read transcriptomics of purified human cortical cell types exposes glial isoform complexity and disease-relevant transcript architecture.bioRxiv : the preprint server for biology · 2026Article
- Caspase-4 transgenic mice exhibit cytoplasmic TDP-43 accumulation and age-dependent neuropathology.Nature communications · 2026Article
- TDP-43: [GU]-ardian of the transcriptome.Molecular neurodegeneration · 2026Review
- A next-generation HDAC6 inhibitor for amyotrophic lateral sclerosis and frontotemporal dementia.Brain : a journal of neurology · 2026Article
- Modest rescue of RBFOX1 splicing function attenuates Huntington's disease features.Molecular medicine (Cambridge, Mass.) · 2026Article
- TDP43 and hnRNP K Regulate Alternative Splicing of DNAJC5.Cell biology international · 2026Article
- Understanding liquid-liquid phase separation through TDP-43: fundamental principles, subcellular compartmentalisation, and role of solid inclusion formation.Genome biology · 2026Review
- Inhibiting Glycogen Synthase Kinase 3 Suppresses TDP-43-Mediated Neurotoxicity in a Caspase-Dependent Manner.Molecular neurobiology · 2026Article
- Experimental Models and Translational Strategies in Neuroprotective Drug Development with Emphasis on Alzheimer's Disease.Molecules (Basel, Switzerland) · 2026Review
- Molecular Mechanisms and Therapeutic Potential of Degron-Mediated Proteostasis Regulation in Neurodegenerative Diseases.Cellular and molecular neurobiology · 2026Review
- Human TDP-43 overexpression in zebrafish motor neurons triggers MND-like phenotypes through gain-of-function mechanism.Acta neuropathologica communications · 2025Article
- Ultra-Conserved Poison Exons Enable Rapid and Safe Splicing Factor Gene Expression Switches: A Hypothesis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- TDP-43 controls RNA structure through high affinity lattice interactions.bioRxiv : the preprint server for biology · 2025Article
- TDP-43 dysregulation impairs cholesterol metabolism linked with myelination defects.Acta neuropathologica · 2025Article
- Symptomatic treatment by a BBB-permeable AAV engineered to restore TDP-43 function slows motor neuron disease and prevents paralysis.bioRxiv : the preprint server for biology · 2025Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
42 authors at 12 institutions in 5 countries.
Pietro FrattaUCL Institute of Neurology, and MRC Centre for Neuromuscular Disease, London, UK p.fratta@ucl.ac.uk aacevedo@ull.edu.es.ORCID 0000-0002-8762-8188
Prasanth SivakumarUCL Institute of Neurology, and MRC Centre for Neuromuscular Disease, London, UK.
Jack HumphreyUCL Institute of Neurology, and MRC Centre for Neuromuscular Disease, London, UK.
Kitty LoUCL Genetics Institute, London, UK.
Thomas RickettsMRC Mammalian Genetics Unit, Harwell, UK.
Hugo OliveiraMRC Mammalian Genetics Unit, Harwell, UK.
Jose M Brito-ArmasUnidad de Investigación, Hospital Universitario de Canarias, Fundación Canaria de Investigación Sanitaria and Instituto de Tecnologías Biomédicas (CIBICAN), La Laguna, Spain.
Bernadett KalmarUCL Institute of Neurology, and MRC Centre for Neuromuscular Disease, London, UK.
Agnieszka UleUCL Institute of Neurology, and MRC Centre for Neuromuscular Disease, London, UK.
Yichao YuUCL Centre for Advanced Biomedical Imaging, University College London, London, UK.
Nicol BirsaUCL Institute of Neurology, and MRC Centre for Neuromuscular Disease, London, UK.
Cristian BodoUCL Institute of Neurology, and MRC Centre for Neuromuscular Disease, London, UK.
Toby CollinsUCL Institute of Neurology, and MRC Centre for Neuromuscular Disease, London, UK.
Alexander E ConicellaGraduate Program in Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA.
Alan Mejia MazaUCL Institute of Neurology, and MRC Centre for Neuromuscular Disease, London, UK.
Alessandro Marrero-GagliardiUnidad de Investigación, Hospital Universitario de Canarias, Fundación Canaria de Investigación Sanitaria and Instituto de Tecnologías Biomédicas (CIBICAN), La Laguna, Spain.
Michelle StewartMRC Mary Lyon Centre, Harwell, UK.
Joffrey MianneMRC Mary Lyon Centre, Harwell, UK.ORCID 0000-0003-0893-9947
Silvia CorrochanoMRC Mammalian Genetics Unit, Harwell, UK.
Warren EmmettUCL Genetics Institute, London, UK.
Gemma CodnerMRC Mary Lyon Centre, Harwell, UK.
Michael GrovesUCL Institute of Neurology, and MRC Centre for Neuromuscular Disease, London, UK.
Ryutaro FukumuraMutagenesis and Genomics Team, RIKEN BioResource Center, Tsukuba, Ibaraki, Japan.
Yoichi GondoMutagenesis and Genomics Team, RIKEN BioResource Center, Tsukuba, Ibaraki, Japan.
Mark LythgoeUCL Centre for Advanced Biomedical Imaging, University College London, London, UK.
Erwin PauwsUCL Institute of Child Health, London, UK.
Emma PeskettUCL Institute of Child Health, London, UK.
Philip StanierUCL Institute of Child Health, London, UK.ORCID 0000-0001-9340-8117
Lydia TeboulMRC Mary Lyon Centre, Harwell, UK.
Martina HalleggerUCL Institute of Neurology and Francis Crick Institute, London, UK.
Andrea CalvoRita Levi Montalcini Department of Neuroscience, University of Turin, Turin, Italy.
Adriano ChiòRita Levi Montalcini Department of Neuroscience, University of Turin, Turin, Italy.
Adrian M IsaacsUCL Institute of Neurology, and MRC Centre for Neuromuscular Disease, London, UK.ORCID 0000-0002-6820-5534
Nicolas L FawziDepartment of Molecular Pharmacology, Physiology & Biotechnology, Brown University, Providence, RI, USA.ORCID 0000-0001-5483-0577
Eric WangDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
David E HousmanDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Francisco BaralleInternational Center for Genomic Engineering and Biotechnology (ICGEB), Trieste, Italy.
Linda GreensmithUCL Institute of Neurology, and MRC Centre for Neuromuscular Disease, London, UK.
Emanuele BurattiInternational Center for Genomic Engineering and Biotechnology (ICGEB), Trieste, Italy.ORCID 0000-0002-1356-9074
Vincent PlagnolUCL Genetics Institute, London, UK.
Elizabeth Mc FisherUCL Institute of Neurology, and MRC Centre for Neuromuscular Disease, London, UK.
Abraham Acevedo-ArozenaMRC Mammalian Genetics Unit, Harwell, UK p.fratta@ucl.ac.uk aacevedo@ull.edu.es.ORCID 0000-0001-6127-7116
MRC Prion Unit · GBMary Lyon Centre at MRC Harwell · GBUniversity College London · GBHospital Universitario de Canarias · ESBrown University · USInternational Centre for Genetic Engineering and Biotechnology · ITMassachusetts Institute of Technology · USRIKEN BioResource Research Center · JPUCL Biomedical Research Centre · GBUniversity of Turin · ITThe Francis Crick Institute · GBUK Dementia Research Institute · GB
Funding
TRAINING IN MOLECULAR &CELL BIOLOGY &BIOCHEMISTRYT32GM007601 · NIGMS · BROWN UNIVERSITY · PI MOWRY, KIMBERLY L. · 1985 to 2019
$6.4MTurning off the molecular switch for pathological self-assembly of FUSR01GM118530 · NIGMS · BROWN UNIVERSITY · PI FAWZI, NICOLAS LUX · 2016 to 2020
$1.6MMedical Research Council G0500288Medical Research Council G0801110Medical Research Council MC_EX_MR/N501931/1Medical Research Council MC_UP_1502/1Medical Research Council MC_UP_A390_1106Medical Research Council MR/K018523/1Medical Research Council MR/L021056/1Medical Research Council MR/M008606/1Medical Research Council MR/R005184/1Motor Neurone Disease Association FRATTA/JAN15/946-795Motor Neurone Disease Association HALLEGGER/OCT15/959-799NIGMS NIH HHS R01 GM118530NIGMS NIH HHS T32 GM007601
Abstract
TDP-43 (encoded by the gene
Indexed as
Alternative SplicingAmyotrophic Lateral SclerosisAnimalsDNA-Binding ProteinsExonsGene Expression RegulationHumansMiceMotor NeuronsMutationRNA-Binding ProteinsRNA SplicingDNA-Binding ProteinsRNA-Binding ProteinsTardbp protein, mouseALScryptic exonskiptic exonsplicingTDP‐43
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.