ArticleLearning & memory (Cold Spring Harbor, N.Y.)2018
Reinforcement signaling of punishment versus relief in fruit flies.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- Compromising Tyrosine Hydroxylase Function Extends and Blunts the Temporal Profile of Reinforcement by Dopamine Neurons inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Prediction error drives associative learning and conditioned behavior in a spiking model of Drosophila larva.iScience · 2024Article
- Rewarding Capacity of Optogenetically Activating a Giant GABAergic Central-Brain Interneuron in LarvalThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Metamorphosis of memory circuits ineLife · 2023Article
- Dopamine activity in projection neurons regulates short-lasting olfactory approach memory in Drosophila.The European journal of neuroscience · 2022Article
- Article
- Associative learning in larval and adult Drosophila is impaired by the dopamine-synthesis inhibitor 3-Iodo-L-tyrosine.Biology open · 2021Article
- The Role of Dopamine in Associative Learning in Drosophila: An Updated Unified Model.Neuroscience bulletin · 2021Review
- Predictive olfactory learning in Drosophila.Scientific reports · 2021Article
- Spaced Training Forms Complementary Long-Term Memories of Opposite Valence in Drosophila.Neuron · 2020Article
- An optogenetic analogue of second-order reinforcement in Drosophila.Biology letters · 2019Article
- Distinct Dopamine Receptor Pathways Underlie the Temporal Sensitivity of Associative Learning.Cell · 2019Article
- One-trial learning in larvalLearning & memory (Cold Spring Harbor, N.Y.) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Painful events establish opponent memories: cues that precede pain are remembered negatively, whereas cues that follow pain, thus coinciding with relief are recalled positively. How do individual reinforcement-signaling neurons contribute to this "timing-dependent valence-reversal?" We addressed this question using an optogenetic approach in the fruit fly. Two types of fly dopaminergic neuron, each comprising just one paired cell, indeed established learned avoidance of odors that preceded their photostimulation during training, and learned approach to odors that followed the photostimulation. This is in striking parallel to punishment versus relief memories reinforced by a real noxious event. For only one of these neuron types, both effects were strong enough for further analyses. Notably, interfering with dopamine biosynthesis in these neurons partially impaired the punishing effect, but not the relieving after-effect of their photostimulation. We discuss how this finding constraints existing computational models of punishment versus relief memories and introduce a new model, which also incorporates findings from mammals. Furthermore, whether using dopaminergic neuron photostimulation or a real noxious event, more prolonged punishment led to stronger relief. This parametric feature of relief may also apply to other animals and may explain particular aspects of related behavioral dysfunction in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.