Evidence map›Paper›PMID 29764950›Full record

ArticlemBio2018

CagY-Dependent Regulation of Type IV Secretion in Helicobacter pylori Is Associated with Alterations in Integrin Binding.

Emma C Skoog, Vasilios A Morikis, Miriam E Martin, Greg A Foster, Lucy P Cai, Lori M Hansen, Beibei Li, Jennifer A Gaddy, Scott I Simon, Jay V Solnick

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Traditional Chinese medicine in the treatment ofWorld journal of gastroenterology · 2025
    Review
  3. Review
  4. Roles of the components of theFuture microbiology · 2024
    Review
  5. Comparative Analysis of T4SS Molecular Architectures.Journal of microbiology and biotechnology · 2023
    Review
  6. A Proposal for a Consolidated Structural Model of the CagY Protein ofInternational journal of molecular sciences · 2023
    Article
  7. Role of the CagY antenna projection inInfection and immunity · 2023
    Article
  8. Article
  9. Article
  10. Animal Models andJournal of clinical medicine · 2022
    Review
  11. Review
  12. Transcriptional Profile ofThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2021
    Article
  13. Article
  14. Article
  15. International journal of molecular sciences · 2020
    Review
  16. Review
  17. Article
  18. Defining theFrontiers in microbiology · 2020
    Article
  19. Immune Response inGastroenterology research and practice · 2020
    Review
  20. mBio · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Emma C SkoogCenter for Comparative Medicine, University of California, Davis School of Medicine, Davis, California, USA.ORCID 0000-0002-2543-6412
Vasilios A MorikisDepartment of Biomedical Engineering, University of California, Davis School of Medicine, Davis, California, USA.
Miriam E MartinDepartment of Microbiology and Molecular Genetics, University of California, Davis School of Medicine, Davis, California, USA.
Greg A FosterDepartment of Biomedical Engineering, University of California, Davis School of Medicine, Davis, California, USA.
Lucy P CaiCenter for Comparative Medicine, University of California, Davis School of Medicine, Davis, California, USA.
Lori M HansenCenter for Comparative Medicine, University of California, Davis School of Medicine, Davis, California, USA.
Beibei LiCenter for Comparative Medicine, University of California, Davis School of Medicine, Davis, California, USA.
Jennifer A GaddyDepartment of Veterans Affairs, Tennessee Valley Healthcare Systems, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Scott I SimonDepartment of Biomedical Engineering, University of California, Davis School of Medicine, Davis, California, USA.
Jay V SolnickDepartment of Medicine, University of California, Davis School of Medicine, Davis, California, USA jvsolnick@ucdavis.edu.
University of California, Davis · USShanghai Veterinary Research Institute · CNVA Tennessee Valley Healthcare System · US

Funding

Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Outside-in Mechanotransduced Inflammatory TargetsR01AI047294 · NIAID · UNIVERSITY OF CALIFORNIA DAVIS · PI SIMON, SCOTT IRWIN · 1999 to 2021
$7.0M
Animal Models of Infectious Diseases Training ProgramT32AI060555 · NIAID · UNIVERSITY OF CALIFORNIA DAVIS · PI MCSORLEY, STEPHEN J · 2004 to 2025
$3.3M
Functional Plasticity in the Helicobacter pylori Type IV Secretion SystemR01AI108713 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SOLNICK, JAY V. · 2014 to 2018
$2.9M
Regulation of Helicobacter pylori pili encoded by the cag pathogenicity islandIK2BX001701 · VA · VETERANS HEALTH ADMINISTRATION · PI GADDY, JENNIFER A · 2013 to 2017
–
BLRD VA IK2 BX001701NIAID NIH HHS R01 AI047294NIAID NIH HHS R01 AI108713NIAID NIH HHS T32 AI060555NIDDK NIH HHS P30 DK058404
6 · The paper itself

Abstract

Strains of

Indexed as

Amino Acid MotifsBacterial ProteinsGenomic IslandsHelicobacter InfectionsHelicobacter pyloriHost-Pathogen InteractionsHumansIntegrin alpha5Integrin beta1Protein BindingType IV Secretion SystemsBacterial ProteinsIntegrin alpha5Integrin beta1Type IV Secretion SystemsCagACagYHelicobacter pyloriintegrinpathogenicity islandtype IV secretion system

Identifiers

PMID29764950
PMCPMC5954226
OpenAlexW2795376878

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.