ArticlemBio2018
Comparative Genomics Reveals the Core Gene Toolbox for the Fungus-Insect Symbiosis.
Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
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- Single-Thallus Genomics of Ejectosporus trisporus, an Unculturable Stonefly Gut Fungal Symbiont.Environmental microbiology · 2026Article
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- Evolution, multifunctionality, and agricultural potential of insect microbiomes and the holobiont concept.The ISME journal · 2026Review
- From fragmentation to resolution: high-fidelity genome assembly of zancudomyces culisetae through comparative insights from PacBio, Nanopore, and Illumina sequencing.G3 (Bethesda, Md.) · 2025Article
- Harnessing Nutritional Niches to Explore Fungus-Animal Symbioses.Ecology letters · 2025Review
- Three-Dimensional Structural Heteromorphs of Mating-Type Proteins inJournal of fungi (Basel, Switzerland) · 2025Article
- De Novo Long-Read Genome Assembly and Annotation of the Mosquito Gut-Dwelling Fungus, Smittium minutisporum.Genome biology and evolution · 2024Article
- Mutations and Differential Transcription of Mating-Type and Pheromone Receptor Genes inBiology · 2024Article
- Gut Microbial Diversity Reveals Differences in Pathogenicity betweenMicroorganisms · 2024Article
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- Revealing the Diversity of the Mycobiome in Different Phases of Ticks: ITS Gene-Based Analysis.Transboundary and emerging diseases · 2024Article
- Sequencing the Genomes of the First Terrestrial Fungal Lineages: What Have We Learned?Microorganisms · 2023Review
- Divergent Evolution of Early Terrestrial Fungi Reveals the Evolution of Mucormycosis Pathogenicity Factors.Genome biology and evolution · 2023Article
- Speciation Underpinned by Unexpected Molecular Diversity in the Mycorrhizal Fungal Genus Pisolithus.Molecular biology and evolution · 2023Article
- Mycoparasites, Gut Dwellers, and Saprotrophs: Phylogenomic Reconstructions and Comparative Analyses of Kickxellomycotina Fungi.Genome biology and evolution · 2023Article
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- Co-option of an extracellular protease for transcriptional control of nutrient degradation in the fungus Aspergillus nidulans.Communications biology · 2021Article
- Trends in the Immunomodulatory Effects ofFrontiers in pharmacology · 2020Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Modern genomics has shed light on many entomopathogenic fungi and expanded our knowledge widely; however, little is known about the genomic features of the insect-commensal fungi. Harpellales are obligate commensals living in the digestive tracts of disease-bearing insects (black flies, midges, and mosquitoes). In this study, we produced and annotated whole-genome sequences of nine Harpellales taxa and conducted the first comparative analyses to infer the genomic diversity within the members of the Harpellales. The genomes of the insect gut fungi feature low (26% to 37%) GC content and large genome size variations (25 to 102 Mb). Further comparisons with insect-pathogenic fungi (from both Ascomycota and Zoopagomycota), as well as with free-living relatives (as negative controls), helped to identify a gene toolbox that is essential to the fungus-insect symbiosis. The results not only narrow the genomic scope of fungus-insect interactions from several thousands to eight core players but also distinguish host invasion strategies employed by insect pathogens and commensals. The genomic content suggests that insect commensal fungi rely mostly on adhesion protein anchors that target digestive system, while entomopathogenic fungi have higher numbers of transmembrane helices, signal peptides, and pathogen-host interaction (PHI) genes across the whole genome and enrich genes as well as functional domains to inactivate the host inflammation system and suppress the host defense. Phylogenomic analyses have revealed that genome sizes of Harpellales fungi vary among lineages with an integer-multiple pattern, which implies that ancient genome duplications may have occurred within the gut of insects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.