Evidence map›Paper›PMID 29764944›Full record

ArticlemBio2018

RECON-Dependent Inflammation in Hepatocytes Enhances Listeria monocytogenes Cell-to-Cell Spread.

Adelle P McFarland, Thomas P Burke, Alexie A Carletti, Rochelle C Glover, Hannah Tabakh, Matthew D Welch, Joshua J Woodward

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
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  12. The Opposing Role of Propionate in ModulatingFrontiers in microbiology · 2021
    Article
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  15. c-di-AMP hydrolysis by the phosphodiesterase AtaC promotes differentiation of multicellular bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  16. Review
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  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Adelle P McFarlandDepartment of Microbiology, University of Washington, Seattle, Washington, USA.
Thomas P BurkeDepartment of Molecular and Cell Biology, University of California, Berkeley, California, USA.
Alexie A CarlettiDepartment of Microbiology, University of Washington, Seattle, Washington, USA.
Rochelle C GloverDepartment of Microbiology, University of Washington, Seattle, Washington, USA.
Hannah TabakhDepartment of Microbiology, University of Washington, Seattle, Washington, USA.
Matthew D WelchDepartment of Molecular and Cell Biology, University of California, Berkeley, California, USA.ORCID 0000-0003-2537-6349
Joshua J WoodwardDepartment of Microbiology, University of Washington, Seattle, Washington, USA jjwoodwa@uw.edu.
University of Washington · USUniversity of California, Berkeley · US

Funding

TRAINING IN MOLECULAR AND CELLULAR BIOLOGYT32GM007270 · NIGMS · UNIVERSITY OF WASHINGTON · PI RAIBLE, DAVID W · 1985 to 2020
$21.0M
Rickettsia mobilization of the cytoskeleton during invasion, motility, and spreadR01AI109044 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI WELCH, MATTHEW D · 2014 to 2025
$5.6M
Listeria monocytogenes physiology and host pathogen interactionsR01AI116669 · NIAID · UNIVERSITY OF WASHINGTON · PI WOODWARD, JOSHUA · 2015 to 2024
$4.4M
NIAID NIH HHS R01 AI109044NIAID NIH HHS R01 AI116669NIGMS NIH HHS T32 GM007270
6 · The paper itself

Abstract

The oxidoreductase RECON is a high-affinity cytosolic sensor of bacterium-derived cyclic dinucleotides (CDNs). CDN binding inhibits RECON's enzymatic activity and subsequently promotes inflammation. In this study, we sought to characterize the effects of RECON on the infection cycle of the intracellular bacterium

Indexed as

AnimalsCyclic AMPEstradiol DehydrogenasesHepatocytesHumansListeria monocytogenesListeriosisMaleMiceMice, Inbred BALB CNF-kappa BOxidoreductasesAKR1C13 protein, mouseCyclic AMPEstradiol DehydrogenasesNF-kappa BOxidoreductasesactin-based motilityCDNscyclic di-AMPcyclic dinucleotidesiNOSListeria monocytogenesNF-κBnitric oxideoxidoreductaseRECON

Identifiers

PMID29764944
PMCPMC5954220
OpenAlexW2803703843

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.