Evidence map›Paper›PMID 29764923›Full record

ReviewJournal of lipid research2018

Extracellular vesicles: lipids as key components of their biogenesis and functions.

Michel Record, Sandrine Silvente-Poirot, Marc Poirot, Michael J O Wakelam

Open access · hybridAbstract readReview
In one paragraph

Review in Journal of lipid research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 181 papers.

0numbers the graph read from it
0cells of the map it votes in
181citing papers in PubMed
12.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

181 citing papers in PubMed, 315 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. The relevance of membrane lipid composition in exosome-based precision dermatology.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Article
  6. Review
  7. Research progress on biomarkers of traumatic brain injury.Animal models and experimental medicine · 2026
    Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Structural and Functional Characterization of EXPO-Derived Extracellular Vesicles in Plants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  15. Article
  16. Article
  17. Decoding the Role of Lipid Metabolism and Membrane Dynamics in Melanoma.International journal of molecular sciences · 2026
    Review
  18. Review
  19. Review
  20. Review

121 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Michel RecordUMR INSERM 1037-CRCT (Cancer Research Center of Toulouse), University of Toulouse III Paul Sabatier, Team "Cholesterol Metabolism and Therapeutic Innovations," Toulouse, France michel.record@inserm.fr.
Sandrine Silvente-PoirotUMR INSERM 1037-CRCT (Cancer Research Center of Toulouse), University of Toulouse III Paul Sabatier, Team "Cholesterol Metabolism and Therapeutic Innovations," Toulouse, France.
Marc PoirotUMR INSERM 1037-CRCT (Cancer Research Center of Toulouse), University of Toulouse III Paul Sabatier, Team "Cholesterol Metabolism and Therapeutic Innovations," Toulouse, France.
Michael J O WakelamBabraham Institute, Babraham Research Campus, Cambridge, United Kingdom.
Inserm · FRBabraham Institute · GB

Funding

Biotechnology and Biological Sciences Research Council BBS/E/B/0000S227Biotechnology and Biological Sciences Research Council BBS/E/B/000C0411Cancer Research UK 18720
6 · The paper itself

Abstract

Intercellular communication has been known for decades to involve either direct contact between cells or to operate via circulating molecules, such as cytokines, growth factors, or lipid mediators. During the last decade, we have begun to appreciate the increasing importance of intercellular communication mediated by extracellular vesicles released by viable cells either from plasma membrane shedding (microvesicles, also named microparticles) or from an intracellular compartment (exosomes). Exosomes and microvesicles circulate in all biological fluids and can trigger biological responses at a distance. Their effects include a large variety of biological processes, such as immune surveillance, modification of tumor microenvironment, or regulation of inflammation. Extracellular vesicles can carry a large array of active molecules, including lipid mediators, such as eicosanoids, proteins, and nucleic acids, able to modify the phenotype of receiving cells. This review will highlight the role of the various lipidic pathways involved in the biogenesis and functions of microvesicles and exosomes.

Indexed as

Lipid MetabolismCell-Derived MicroparticlesExosomesExtracellular VesiclesHumansSignal Transductionlipid kinaseslipid transporterslipolytic enzymesmembrane asymmetrymembrane fusion

Identifiers

PMID29764923
PMCPMC6071772
OpenAlexW2804173945

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.